| http://purl.uniprot.org/citations/20413611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20413611 | http://www.w3.org/2000/01/rdf-schema#comment | "How transcription factors interpret the cis-regulatory logic encoded within enhancers to mediate quantitative changes in spatiotemporally restricted expression patterns during animal development is not well understood. Pax6 is a dosage-sensitive gene essential for eye development. Here, we identify the Prep1 (pKnox1) transcription factor as a critical dose-dependent upstream regulator of Pax6 expression during lens formation. We show that Prep1 activates the Pax6 lens enhancer by binding to two phylogenetically conserved lower-affinity DNA-binding sites. Finally, we describe a mechanism whereby Pax6 levels are determined by transcriptional synergy of Prep1 bound to the two sites, while timing of enhancer activation is determined by binding site affinity."xsd:string |
| http://purl.uniprot.org/citations/20413611 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.1890410"xsd:string |
| http://purl.uniprot.org/citations/20413611 | http://purl.uniprot.org/core/author | "Yue Y."xsd:string |
| http://purl.uniprot.org/citations/20413611 | http://purl.uniprot.org/core/author | "Bulyk M.L."xsd:string |
| http://purl.uniprot.org/citations/20413611 | http://purl.uniprot.org/core/author | "Lachke S.A."xsd:string |
| http://purl.uniprot.org/citations/20413611 | http://purl.uniprot.org/core/author | "Rowan S."xsd:string |
| http://purl.uniprot.org/citations/20413611 | http://purl.uniprot.org/core/author | "Siggers T."xsd:string |
| http://purl.uniprot.org/citations/20413611 | http://purl.uniprot.org/core/author | "Maas R.L."xsd:string |
| http://purl.uniprot.org/citations/20413611 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20413611 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/20413611 | http://purl.uniprot.org/core/pages | "980-985"xsd:string |
| http://purl.uniprot.org/citations/20413611 | http://purl.uniprot.org/core/title | "Precise temporal control of the eye regulatory gene Pax6 via enhancer-binding site affinity."xsd:string |
| http://purl.uniprot.org/citations/20413611 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/20413611 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20413611 |
| http://purl.uniprot.org/citations/20413611 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20413611 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MQB8-mappedCitation-20413611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20413611 |
| http://purl.uniprot.org/uniprot/#_A0A0A7EPH8-mappedCitation-20413611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20413611 |
| http://purl.uniprot.org/uniprot/#_P63015-mappedCitation-20413611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20413611 |
| http://purl.uniprot.org/uniprot/#_A0A494B900-mappedCitation-20413611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20413611 |
| http://purl.uniprot.org/uniprot/#_A0A494B934-mappedCitation-20413611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20413611 |
| http://purl.uniprot.org/uniprot/#_A0A494B958-mappedCitation-20413611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20413611 |
| http://purl.uniprot.org/uniprot/#_A2A409-mappedCitation-20413611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20413611 |
| http://purl.uniprot.org/uniprot/#_A2A412-mappedCitation-20413611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20413611 |
| http://purl.uniprot.org/uniprot/#_A0A494B9U0-mappedCitation-20413611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20413611 |