| http://purl.uniprot.org/citations/20421423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20421423 | http://www.w3.org/2000/01/rdf-schema#comment | "Ca(2+)/calmodulin kinase II (CaMKII) plays an important role in cardiac contractility and the development of heart failure. Although stimulation of beta(1)-adrenergic receptors (ARs) leads to an increase in CaMKII activity, the molecular mechanism by which beta(1)-ARs activate CaMKII is not completely understood. In this study, we show the requirement for the beta(1)-AR regulatory protein beta-arrestin as a scaffold for both CaMKII and Epac (exchange protein directly activated by cAMP). Stimulation of beta(1)-ARs induces the formation of a beta-arrestin-CaMKII-Epac1 complex, allowing its recruitment to the plasma membrane, whereby interaction with cAMP leads to CaMKII activation. beta-Arrestin binding to the carboxyl-terminal tail of beta(1)-ARs promotes a conformational change within beta-arrestin that allows CaMKII and Epac to remain in a stable complex with the receptor. The essential role for beta-arrestin and identification of the molecular mechanism by which only beta(1)-ARs and not beta(2)-ARs activate CaMKII significantly advances our understanding of this important cellular pathway."xsd:string |
| http://purl.uniprot.org/citations/20421423 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200911047"xsd:string |
| http://purl.uniprot.org/citations/20421423 | http://purl.uniprot.org/core/author | "Shukla A.K."xsd:string |
| http://purl.uniprot.org/citations/20421423 | http://purl.uniprot.org/core/author | "Rockman H.A."xsd:string |
| http://purl.uniprot.org/citations/20421423 | http://purl.uniprot.org/core/author | "Mangmool S."xsd:string |
| http://purl.uniprot.org/citations/20421423 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20421423 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/20421423 | http://purl.uniprot.org/core/pages | "573-587"xsd:string |
| http://purl.uniprot.org/citations/20421423 | http://purl.uniprot.org/core/title | "beta-Arrestin-dependent activation of Ca(2+)/calmodulin kinase II after beta(1)-adrenergic receptor stimulation."xsd:string |
| http://purl.uniprot.org/citations/20421423 | http://purl.uniprot.org/core/volume | "189"xsd:string |
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