| http://purl.uniprot.org/citations/20421478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20421478 | http://www.w3.org/2000/01/rdf-schema#comment | "NK cell-mediated murine cytomegalovirus (MCMV) resistance (Cmv(r)) is under H-2(k) control in MA/My mice, but the underlying gene(s) is unclear. Prior genetic analysis mapped Cmv(r) to the MHC class I (MHC-I) D(k) gene interval. Because NK cell receptors are licensed by and responsive to MHC class I molecules, D(k) itself is a candidate gene. A 10-kb genomic D(k) fragment was subcloned and microinjected into MCMV-susceptible (Cmv(s)) (MA/My.L-H2(b) x C57L)F(1) or (B6 x DBA/2)F(2) embryos. Transgenic founders, which are competent for D(k) expression and germline transgene transmission, were identified and further backcrossed to MA/My.L-H2(b) or C57L mice. Remarkably, D(k) expression delivered NK-mediated resistance in either genetic background. Further, NK cells with cognate inhibitory Ly49G receptors for self-MHC-I D(k) were licensed and critical in protection against MCMV infection. In radiation bone marrow chimeras, NK resistance was significantly diminished when MHC-I D(k) expression was restricted to only hematopoietic or nonhematopoietic cells. Thus, MHC-I D(k) is the H-2(k)-linked Cmv(r) locus; these findings suggest a role for NK cell interaction with D(k)-bearing hematopoietic and nonhematopoietic cells to shape NK-mediated virus immunity."xsd:string |
| http://purl.uniprot.org/citations/20421478 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0913126107"xsd:string |
| http://purl.uniprot.org/citations/20421478 | http://purl.uniprot.org/core/author | "Xu W."xsd:string |
| http://purl.uniprot.org/citations/20421478 | http://purl.uniprot.org/core/author | "Xie X."xsd:string |
| http://purl.uniprot.org/citations/20421478 | http://purl.uniprot.org/core/author | "Lundgren A."xsd:string |
| http://purl.uniprot.org/citations/20421478 | http://purl.uniprot.org/core/author | "Brown M.G."xsd:string |
| http://purl.uniprot.org/citations/20421478 | http://purl.uniprot.org/core/author | "Makrigiannis A.P."xsd:string |
| http://purl.uniprot.org/citations/20421478 | http://purl.uniprot.org/core/author | "Stadnisky M.D."xsd:string |
| http://purl.uniprot.org/citations/20421478 | http://purl.uniprot.org/core/author | "Ahmed Rahim M.M."xsd:string |
| http://purl.uniprot.org/citations/20421478 | http://purl.uniprot.org/core/author | "Coats E.R."xsd:string |
| http://purl.uniprot.org/citations/20421478 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20421478 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/20421478 | http://purl.uniprot.org/core/pages | "8754-8759"xsd:string |
| http://purl.uniprot.org/citations/20421478 | http://purl.uniprot.org/core/title | "MHC class I D(k) expression in hematopoietic and nonhematopoietic cells confers natural killer cell resistance to murine cytomegalovirus."xsd:string |
| http://purl.uniprot.org/citations/20421478 | http://purl.uniprot.org/core/volume | "107"xsd:string |
| http://purl.uniprot.org/citations/20421478 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20421478 |
| http://purl.uniprot.org/citations/20421478 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20421478 |
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| http://purl.uniprot.org/uniprot/#_A0A0E3URM8-mappedCitation-20421478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20421478 |
| http://purl.uniprot.org/uniprot/#_A0A0E3URM9-mappedCitation-20421478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20421478 |
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| http://purl.uniprot.org/uniprot/#_A0A0F6Q8J3-mappedCitation-20421478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20421478 |