| http://purl.uniprot.org/citations/20427468 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20427468 | http://www.w3.org/2000/01/rdf-schema#comment | "Thyroid hormone (TH) plays a critical role in development, growth, and metabolism by binding to nuclear TH receptors to modulate gene expression. In the absence of TH, TH receptors repress genes that are TH-activated by recruiting the nuclear receptor corepressor (NCoR), which exists in a tight complex with histone deacetylase 3 (HDAC3). Here we explored the actions of TH in the deacetylase activating domain mutant (DADm) mouse, whose NCoR-HDAC3 interaction is genetically disrupted. Several TH-activated genes were derepressed in the liver of euthyroid and hypothyroid DADm mice, consistent with the corepressor paradigm and a critical role of the NCoR-HDAC3 interaction in basal repression. The role of corepressors in genes that are down-regulated by TH is less well understood. Remarkably, circulating TSH levels were increased in euthyroid DADm mice, and the pituitary expression of TSHalpha, a classic TH-down-regulated gene, was modestly but significantly elevated regardless of TH status. Thus, the NCoR interaction with HDAC3 modulates expression of both positively- and negatively-regulated genes by TH in vivo."xsd:string |
| http://purl.uniprot.org/citations/20427468 | http://purl.org/dc/terms/identifier | "doi:10.1210/me.2009-0501"xsd:string |
| http://purl.uniprot.org/citations/20427468 | http://purl.uniprot.org/core/author | "Liao X."xsd:string |
| http://purl.uniprot.org/citations/20427468 | http://purl.uniprot.org/core/author | "Lazar M.A."xsd:string |
| http://purl.uniprot.org/citations/20427468 | http://purl.uniprot.org/core/author | "Weiss R.E."xsd:string |
| http://purl.uniprot.org/citations/20427468 | http://purl.uniprot.org/core/author | "You S.H."xsd:string |
| http://purl.uniprot.org/citations/20427468 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20427468 | http://purl.uniprot.org/core/name | "Mol Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/20427468 | http://purl.uniprot.org/core/pages | "1359-1367"xsd:string |
| http://purl.uniprot.org/citations/20427468 | http://purl.uniprot.org/core/title | "The interaction between nuclear receptor corepressor and histone deacetylase 3 regulates both positive and negative thyroid hormone action in vivo."xsd:string |
| http://purl.uniprot.org/citations/20427468 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/20427468 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20427468 |
| http://purl.uniprot.org/citations/20427468 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20427468 |
| http://purl.uniprot.org/uniprot/#_A0A0G2K2B4-mappedCitation-20427468 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20427468 |
| http://purl.uniprot.org/uniprot/#_E9Q9Y2-mappedCitation-20427468 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20427468 |
| http://purl.uniprot.org/uniprot/#_E0CYX5-mappedCitation-20427468 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20427468 |
| http://purl.uniprot.org/uniprot/#_A0A494B9Q7-mappedCitation-20427468 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20427468 |
| http://purl.uniprot.org/uniprot/#_A6HF98-mappedCitation-20427468 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20427468 |
| http://purl.uniprot.org/uniprot/#_A6HFA1-mappedCitation-20427468 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20427468 |
| http://purl.uniprot.org/uniprot/#_F7C134-mappedCitation-20427468 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20427468 |
| http://purl.uniprot.org/uniprot/#_E9Q2B2-mappedCitation-20427468 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20427468 |
| http://purl.uniprot.org/uniprot/#_E9Q8K6-mappedCitation-20427468 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20427468 |
| http://purl.uniprot.org/uniprot/#_F6TRR6-mappedCitation-20427468 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20427468 |
| http://purl.uniprot.org/uniprot/#_F6TWR1-mappedCitation-20427468 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20427468 |