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| http://purl.uniprot.org/citations/20427576 | http://www.w3.org/2000/01/rdf-schema#comment | "Caveolin-1 and caveolae are often lost in cancer. We found that levels of caveolin-1 and polymerase I and transcript release factor (PTRF)/cavin-1 correlated closely in a panel of cancer and normal cells. Caveolin-1 reexpression in cancer cells lacking both proteins induced formation of long membrane tubules rarely seen in normal cells. PTRF/cavin-1 inhibited tubule formation when coexpressed with caveolin-1 in these cells, whereas suppression of PTRF/cavin-1 expression in cells that normally expressed both genes stimulated tubule formation by endogenous caveolin-1. Caveolin-1 tubules shared several features with previously described Rab8 tubules. Coexpressed Rab8 and caveolin-1 labeled the same tubules (as did EHD proteins), and synergized to promote tubule formation, whereas a dominant-interfering Rab8 mutant inhibited caveolin-1 tubule formation. Both overexpression and inhibition of dynamin-2 reduced the abundance of caveolin-1 tubules. Caveolin-1 reexpression in SK-BR-3 breast cancer cells also induced formation of short membrane tubules close to cortical actin filaments, which required actin filaments but not microtubules. Actomyosin-induced tension destabilized both long and short tubules; they often snapped and resolved to small vesicles. Actin filament depolymerization or myosin II inhibition reduced tension and stabilized tubules. These data demonstrate a new function for PTRF/cavin-1, a new functional interaction between caveolin-1 and Rab8 and that actomyosin interactions can induce tension on caveolin-1-containing membranes."xsd:string |
| http://purl.uniprot.org/citations/20427576 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e09-05-0417"xsd:string |
| http://purl.uniprot.org/citations/20427576 | http://purl.uniprot.org/core/author | "Verma P."xsd:string |
| http://purl.uniprot.org/citations/20427576 | http://purl.uniprot.org/core/author | "Brown D.A."xsd:string |
| http://purl.uniprot.org/citations/20427576 | http://purl.uniprot.org/core/author | "Ostermeyer-Fay A.G."xsd:string |
| http://purl.uniprot.org/citations/20427576 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20427576 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/20427576 | http://purl.uniprot.org/core/pages | "2226-2240"xsd:string |
| http://purl.uniprot.org/citations/20427576 | http://purl.uniprot.org/core/title | "Caveolin-1 induces formation of membrane tubules that sense actomyosin tension and are inhibited by polymerase I and transcript release factor/cavin-1."xsd:string |
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