| http://purl.uniprot.org/citations/20441996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20441996 | http://www.w3.org/2000/01/rdf-schema#comment | "We aimed to clarify the role of matrix metalloproteinases (MMP) as a possible link between neurodegeneration and skin pathology in ALS by determination of gelatinase MMP-2 and MMP-9 in spinal cord and skin of transgenic SOD1((G93A)) mice. To elucidate mechanisms influencing MMPs, markers of oxidative damage (malondialdehyde (MDA), 3-nitrotyrosine (3-NT) and 8-hydroxy-2'-deoxyguanosine (8OH2'dG)) as well as cytokines (tumor necrosis factor alpha (TNF-alpha) and interleukin 1ss (IL-1ss)) were determined. We measured MMP-9, MMP-2, 3-NT, TNF-alpha, and IL-1ss using ELISA, MDA using High Performance Liquid Chromatography (HPLC) and 8OH2'dG using HPLC with electrochemical detection (HPLC-ECD) in SOD1 and WT. MMP-9 was elevated in spinal cord and skin of SOD1 at 90 days (p=0.009, p<0.001) and 120 days (p<0.01, p=0.04). MMP-2 was elevated in the spinal cord at 90 days (p=0.01) and in the skin at 120 days (p=0.039). We observed a correlation of MMP-9 in spinal cord and skin of SOD1 (p=0.04). MDA was elevated in the spinal cord of SOD1 at 90 and 120 days (p=0.00006, p=0.01) and 8OH2'dG at 90 days (p=0.048). IL-1ss was elevated in the spinal cord of SOD1 at 120 days (p=0.02). Our data confirms that gelatinase MMPs are a common factor linking neurodegeneration and skin changes in ALS. It suggests that oxidative stress and microglial-derived cytokines contribute to the elevation of gelatinase MMPs especially in later stages of disease. Our data raises the question whether the skin may function as a biomarker for specific aspects of disease pathology in ALS."xsd:string |
| http://purl.uniprot.org/citations/20441996 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jns.2010.04.005"xsd:string |
| http://purl.uniprot.org/citations/20441996 | http://purl.uniprot.org/core/author | "Fang L."xsd:string |
| http://purl.uniprot.org/citations/20441996 | http://purl.uniprot.org/core/author | "Ludolph A.C."xsd:string |
| http://purl.uniprot.org/citations/20441996 | http://purl.uniprot.org/core/author | "Dorst J."xsd:string |
| http://purl.uniprot.org/citations/20441996 | http://purl.uniprot.org/core/author | "Tumani H."xsd:string |
| http://purl.uniprot.org/citations/20441996 | http://purl.uniprot.org/core/author | "Scharffetter-Kochanek K."xsd:string |
| http://purl.uniprot.org/citations/20441996 | http://purl.uniprot.org/core/author | "Wlaschek M."xsd:string |
| http://purl.uniprot.org/citations/20441996 | http://purl.uniprot.org/core/author | "Brettschneider J."xsd:string |
| http://purl.uniprot.org/citations/20441996 | http://purl.uniprot.org/core/author | "Teuchert M."xsd:string |
| http://purl.uniprot.org/citations/20441996 | http://purl.uniprot.org/core/author | "Hendrich C."xsd:string |
| http://purl.uniprot.org/citations/20441996 | http://purl.uniprot.org/core/author | "Huber-Abel F."xsd:string |
| http://purl.uniprot.org/citations/20441996 | http://purl.uniprot.org/core/author | "Schattauer D."xsd:string |
| http://purl.uniprot.org/citations/20441996 | http://purl.uniprot.org/core/author | "Zettlmeissel H."xsd:string |
| http://purl.uniprot.org/citations/20441996 | http://purl.uniprot.org/core/author | "Kapfer T."xsd:string |
| http://purl.uniprot.org/citations/20441996 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20441996 | http://purl.uniprot.org/core/name | "J Neurol Sci"xsd:string |
| http://purl.uniprot.org/citations/20441996 | http://purl.uniprot.org/core/pages | "51-56"xsd:string |
| http://purl.uniprot.org/citations/20441996 | http://purl.uniprot.org/core/title | "MMP-2 and MMP-9 are elevated in spinal cord and skin in a mouse model of ALS."xsd:string |
| http://purl.uniprot.org/citations/20441996 | http://purl.uniprot.org/core/volume | "294"xsd:string |
| http://purl.uniprot.org/citations/20441996 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20441996 |
| http://purl.uniprot.org/citations/20441996 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20441996 |
| http://purl.uniprot.org/uniprot/#_P41245-mappedCitation-20441996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20441996 |
| http://purl.uniprot.org/uniprot/#_Q2M4J5-mappedCitation-20441996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20441996 |