| http://purl.uniprot.org/citations/20444422 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20444422 | http://www.w3.org/2000/01/rdf-schema#comment | "The insulin/TOR signaling pathway plays a crucial role in animal homeostasis, sensing nutrient status to regulate organismal growth and metabolism. We identify here the Drosophila B' regulatory subunit of PP2A (PP2A-B') as a novel, conserved component of the insulin pathway that specifically targets the PP2A holoenzyme to dephosphorylate S6K. PP2A-B' knockout flies have elevated S6K phosphorylation and exhibit phenotypes typical of elevated insulin signaling such as reduced total body triglycerides and reduced longevity. We show that PP2A-B' interacts with S6K both physically and genetically. The human homolog of PP2A-B', PPP2R5C, also counteracts S6K1 phosphorylation, indicating a conserved mechanism in mammals. Since S6K affects development of cancer and metabolic disease, our data identify PPP2R5C as a novel factor of potential medical relevance."xsd:string |
| http://purl.uniprot.org/citations/20444422 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2010.03.015"xsd:string |
| http://purl.uniprot.org/citations/20444422 | http://purl.uniprot.org/core/author | "Miranda M."xsd:string |
| http://purl.uniprot.org/citations/20444422 | http://purl.uniprot.org/core/author | "Teleman A.A."xsd:string |
| http://purl.uniprot.org/citations/20444422 | http://purl.uniprot.org/core/author | "Zorzano A."xsd:string |
| http://purl.uniprot.org/citations/20444422 | http://purl.uniprot.org/core/author | "Hahn K."xsd:string |
| http://purl.uniprot.org/citations/20444422 | http://purl.uniprot.org/core/author | "Vendrell J."xsd:string |
| http://purl.uniprot.org/citations/20444422 | http://purl.uniprot.org/core/author | "Francis V.A."xsd:string |
| http://purl.uniprot.org/citations/20444422 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20444422 | http://purl.uniprot.org/core/name | "Cell Metab"xsd:string |
| http://purl.uniprot.org/citations/20444422 | http://purl.uniprot.org/core/pages | "438-444"xsd:string |
| http://purl.uniprot.org/citations/20444422 | http://purl.uniprot.org/core/title | "PP2A regulatory subunit PP2A-B' counteracts S6K phosphorylation."xsd:string |
| http://purl.uniprot.org/citations/20444422 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/20444422 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20444422 |
| http://purl.uniprot.org/citations/20444422 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20444422 |
| http://purl.uniprot.org/uniprot/Q8IN89#attribution-494E1AA5CD99FAF204DB05138B6E63BD | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20444422 |
| http://purl.uniprot.org/uniprot/Q8IN89#attribution-DB9ABA320879481C4305A37814C1FD41 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20444422 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHP7-mappedCitation-20444422 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20444422 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHB9-mappedCitation-20444422 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20444422 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LGZ3-mappedCitation-20444422 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20444422 |
| http://purl.uniprot.org/uniprot/#_B7Z0L6-mappedCitation-20444422 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20444422 |
| http://purl.uniprot.org/uniprot/#_B7Z0L7-mappedCitation-20444422 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20444422 |
| http://purl.uniprot.org/uniprot/#_C8VV30-mappedCitation-20444422 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20444422 |
| http://purl.uniprot.org/uniprot/#_P36872-mappedCitation-20444422 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20444422 |