| http://purl.uniprot.org/citations/20448110 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20448110 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20448110 | http://www.w3.org/2000/01/rdf-schema#comment | "Type 1 T regulatory (Tr1) cells suppress immune responses in vivo and in vitro and play a key role in maintaining tolerance to self- and non-self-antigens. Interleukin-10 (IL-10) is the crucial driving factor for Tr1 cell differentiation, but the molecular mechanisms underlying this induction remain unknown. We identified and characterized a subset of IL-10-producing human dendritic cells (DCs), termed DC-10, which are present in vivo and can be induced in vitro in the presence of IL-10. DC-10 are CD14(+), CD16(+), CD11c(+), CD11b(+), HLA-DR(+), CD83(+), CD1a(-), CD1c(-), express the Ig-like transcripts (ILTs) ILT2, ILT3, ILT4, and HLA-G antigen, display high levels of CD40 and CD86, and up-regulate CD80 after differentiation in vitro. DC-10 isolated from peripheral blood or generated in vitro are potent inducers of antigen-specific IL-10-producing Tr1 cells. Induction of Tr1 cells by DC-10 is IL-10-dependent and requires the ILT4/HLA-G signaling pathway. Our data indicate that DC-10 represents a novel subset of tolerogenic DCs, which secrete high levels of IL-10, express ILT4 and HLA-G, and have the specific function to induce Tr1 cells."xsd:string |
| http://purl.uniprot.org/citations/20448110 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2009-07-234872"xsd:string |
| http://purl.uniprot.org/citations/20448110 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2009-07-234872"xsd:string |
| http://purl.uniprot.org/citations/20448110 | http://purl.uniprot.org/core/author | "Roncarolo M.G."xsd:string |
| http://purl.uniprot.org/citations/20448110 | http://purl.uniprot.org/core/author | "Roncarolo M.G."xsd:string |
| http://purl.uniprot.org/citations/20448110 | http://purl.uniprot.org/core/author | "Battaglia M."xsd:string |
| http://purl.uniprot.org/citations/20448110 | http://purl.uniprot.org/core/author | "Battaglia M."xsd:string |
| http://purl.uniprot.org/citations/20448110 | http://purl.uniprot.org/core/author | "Gregori S."xsd:string |
| http://purl.uniprot.org/citations/20448110 | http://purl.uniprot.org/core/author | "Gregori S."xsd:string |
| http://purl.uniprot.org/citations/20448110 | http://purl.uniprot.org/core/author | "Hauben E."xsd:string |
| http://purl.uniprot.org/citations/20448110 | http://purl.uniprot.org/core/author | "Hauben E."xsd:string |
| http://purl.uniprot.org/citations/20448110 | http://purl.uniprot.org/core/author | "Magnani C.F."xsd:string |
| http://purl.uniprot.org/citations/20448110 | http://purl.uniprot.org/core/author | "Magnani C.F."xsd:string |
| http://purl.uniprot.org/citations/20448110 | http://purl.uniprot.org/core/author | "Pacciani V."xsd:string |
| http://purl.uniprot.org/citations/20448110 | http://purl.uniprot.org/core/author | "Pacciani V."xsd:string |
| http://purl.uniprot.org/citations/20448110 | http://purl.uniprot.org/core/author | "Scirpoli M."xsd:string |
| http://purl.uniprot.org/citations/20448110 | http://purl.uniprot.org/core/author | "Scirpoli M."xsd:string |
| http://purl.uniprot.org/citations/20448110 | http://purl.uniprot.org/core/author | "Tomasoni D."xsd:string |
| http://purl.uniprot.org/citations/20448110 | http://purl.uniprot.org/core/author | "Tomasoni D."xsd:string |
| http://purl.uniprot.org/citations/20448110 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20448110 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20448110 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/20448110 | http://purl.uniprot.org/core/name | "Blood"xsd:string |