| http://purl.uniprot.org/citations/20453843 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20453843 | http://www.w3.org/2000/01/rdf-schema#comment | "Memory B and plasma cells (PCs) are generated in the germinal center (GC). Because follicular helper T cells (T(FH) cells) have high expression of the immunoinhibitory receptor PD-1, we investigated the role of PD-1 signaling in the humoral response. We found that the PD-1 ligands PD-L1 and PD-L2 were upregulated on GC B cells. Mice deficient in PD-L2 (Pdcd1lg2(-/-)), PD-L1 and PD-L2 (Cd274(-/-)Pdcd1lg2(-/-)) or PD-1 (Pdcd1(-/-)) had fewer long-lived PCs. The mechanism involved more GC cell death and less T(FH) cell cytokine production in the absence of PD-1; the effect was selective, as remaining PCs had greater affinity for antigen. PD-1 expression on T cells and PD-L2 expression on B cells controlled T(FH) cell and PC numbers. Thus, PD-1 regulates selection and survival in the GC, affecting the quantity and quality of long-lived PCs."xsd:string |
| http://purl.uniprot.org/citations/20453843 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.1877"xsd:string |
| http://purl.uniprot.org/citations/20453843 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/20453843 | http://purl.uniprot.org/core/author | "Shlomchik M.J."xsd:string |
| http://purl.uniprot.org/citations/20453843 | http://purl.uniprot.org/core/author | "Sharpe A.H."xsd:string |
| http://purl.uniprot.org/citations/20453843 | http://purl.uniprot.org/core/author | "Tomayko M.M."xsd:string |
| http://purl.uniprot.org/citations/20453843 | http://purl.uniprot.org/core/author | "Good-Jacobson K.L."xsd:string |
| http://purl.uniprot.org/citations/20453843 | http://purl.uniprot.org/core/author | "Szumilas C.G."xsd:string |
| http://purl.uniprot.org/citations/20453843 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20453843 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/20453843 | http://purl.uniprot.org/core/pages | "535-542"xsd:string |
| http://purl.uniprot.org/citations/20453843 | http://purl.uniprot.org/core/title | "PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells."xsd:string |
| http://purl.uniprot.org/citations/20453843 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/20453843 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20453843 |
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