| http://purl.uniprot.org/citations/20453844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20453844 | http://www.w3.org/2000/01/rdf-schema#comment | "Intracellular nucleic acid sensors detect microbial RNA and DNA and trigger the production of type I interferon. However, the cytosolic nucleic acid-sensing system remains to be fully identified. Here we show that the cytosolic nucleic acid-binding protein LRRFIP1 contributed to the production of interferon-beta (IFN-beta) induced by vesicular stomatitis virus (VSV) and Listeria monocytogenes in macrophages. LRRFIP1 bound exogenous nucleic acids and increased the expression of IFN-beta induced by both double-stranded RNA and double-stranded DNA. LRRFIP1 interacted with beta-catenin and promoted the activation of beta-catenin, which increased IFN-beta expression by binding to the C-terminal domain of the transcription factor IRF3 and recruiting the acetyltransferase p300 to the IFN-beta enhanceosome via IRF3. Therefore, LRRFIP1 and its downstream partner beta-catenin constitute another coactivator pathway for IRF3-mediated production of type I interferon."xsd:string |
| http://purl.uniprot.org/citations/20453844 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.1876"xsd:string |
| http://purl.uniprot.org/citations/20453844 | http://purl.uniprot.org/core/author | "Cao X."xsd:string |
| http://purl.uniprot.org/citations/20453844 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/20453844 | http://purl.uniprot.org/core/author | "Zheng Y."xsd:string |
| http://purl.uniprot.org/citations/20453844 | http://purl.uniprot.org/core/author | "Yang P."xsd:string |
| http://purl.uniprot.org/citations/20453844 | http://purl.uniprot.org/core/author | "Wen M."xsd:string |
| http://purl.uniprot.org/citations/20453844 | http://purl.uniprot.org/core/author | "An H."xsd:string |
| http://purl.uniprot.org/citations/20453844 | http://purl.uniprot.org/core/author | "Rui Y."xsd:string |
| http://purl.uniprot.org/citations/20453844 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20453844 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/20453844 | http://purl.uniprot.org/core/pages | "487-494"xsd:string |
| http://purl.uniprot.org/citations/20453844 | http://purl.uniprot.org/core/title | "The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway."xsd:string |
| http://purl.uniprot.org/citations/20453844 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/20453844 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20453844 |
| http://purl.uniprot.org/citations/20453844 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20453844 |
| http://purl.uniprot.org/uniprot/#_A0A087WPT0-mappedCitation-20453844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20453844 |
| http://purl.uniprot.org/uniprot/#_D3Z7S6-mappedCitation-20453844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20453844 |
| http://purl.uniprot.org/uniprot/#_A0A087WNU6-mappedCitation-20453844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20453844 |
| http://purl.uniprot.org/uniprot/#_A0A087WPK3-mappedCitation-20453844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20453844 |
| http://purl.uniprot.org/uniprot/#_A0A087WSF5-mappedCitation-20453844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20453844 |
| http://purl.uniprot.org/uniprot/#_E9Q9T1-mappedCitation-20453844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20453844 |
| http://purl.uniprot.org/uniprot/#_D3Z5Q1-mappedCitation-20453844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20453844 |
| http://purl.uniprot.org/uniprot/#_E9Q6A9-mappedCitation-20453844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20453844 |