| http://purl.uniprot.org/citations/20456299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20456299 | http://www.w3.org/2000/01/rdf-schema#comment | "Dietary restriction (DR) results in a robust increase in lifespan while maintaining the physiology of much younger animals in a wide range of species. Here, we examine the role of drr-2, a DR-responsive gene recently identified, in determining the longevity of Caenorhabditis elegans. Inhibition of drr-2 has been shown to increase longevity. However, the molecular mechanisms by which drr-2 influences longevity remain unknown. We report here that drr-2 encodes an ortholog of human eukaryotic translation initiation factor 4H (eIF4H), whose function is to mediate the initiation step of mRNA translation. The molecular function of DRR-2 is validated by the association of DRR-2 with polysomes and by the decreased rate of protein synthesis observed in drr-2 knockdown animals. Previous studies have also suggested that DR might trigger a regulated reduction in drr-2 expression to initiate its longevity response. By examining the effect of increasing drr-2 expression on DR animals, we find that drr-2 is essential for a large portion of the longevity response to DR. The nutrient-sensing target of rapamycin (TOR) pathway has been shown to mediate the longevity effects of DR in C. elegans. Results from our genetic analyses suggest that eIF4H/DRR-2 functions downstream of TOR, but in parallel to the S6K/PHA-4 pathway to mediate the lifespan effects of DR. Together, our findings reveal an important role for eIF4H/drr-2 in the TOR-mediated longevity responses to DR."xsd:string |
| http://purl.uniprot.org/citations/20456299 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1474-9726.2010.00580.x"xsd:string |
| http://purl.uniprot.org/citations/20456299 | http://purl.uniprot.org/core/author | "Mehta A."xsd:string |
| http://purl.uniprot.org/citations/20456299 | http://purl.uniprot.org/core/author | "Zhong L."xsd:string |
| http://purl.uniprot.org/citations/20456299 | http://purl.uniprot.org/core/author | "Hsu A.L."xsd:string |
| http://purl.uniprot.org/citations/20456299 | http://purl.uniprot.org/core/author | "Ching T.T."xsd:string |
| http://purl.uniprot.org/citations/20456299 | http://purl.uniprot.org/core/author | "Paal A.B."xsd:string |
| http://purl.uniprot.org/citations/20456299 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20456299 | http://purl.uniprot.org/core/name | "Aging Cell"xsd:string |
| http://purl.uniprot.org/citations/20456299 | http://purl.uniprot.org/core/pages | "545-557"xsd:string |
| http://purl.uniprot.org/citations/20456299 | http://purl.uniprot.org/core/title | "drr-2 encodes an eIF4H that acts downstream of TOR in diet-restriction-induced longevity of C. elegans."xsd:string |
| http://purl.uniprot.org/citations/20456299 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/20456299 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20456299 |
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