| http://purl.uniprot.org/citations/20457807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20457807 | http://www.w3.org/2000/01/rdf-schema#comment | "The receptor tyrosine kinase Ror2 acts as a receptor or coreceptor for Wnt5a to mediate Wnt5a-induced activation of the Wnt/JNK pathway and inhibition of the beta-catenin-dependent canonical Wnt pathway. However, little is known about how Ror2 cooperates with another receptor component(s) to mediate Wnt5a signaling. We show here that Ror2 regulates Wnt5a-induced polymerization of Dishevelled (Dvl) and that this Ror2-mediated regulation of Dvl is independent of the cytoplasmic region of Ror2. Ror2 can associate with Frizzled7 (Fz7) via its extracellular cysteine-rich domain to form a receptor complex that is required for the regulation of Dvl and activation of the AP-1 promoter after Wnt5a stimulation. Suppressed expression of Fz7 indeed results in the inhibition of Wnt5a-induced polymerization of Dvl and AP-1 activation. Interestingly, both the DIX and the DEP domains of Dvl are indispensable for Dvl polymerization and subsequent AP-1 activation after Wnt5a stimulation. We further show that polymerized Dvl is colocalized with Rac1 and that suppressed expression of Rac1 inhibits Wnt5a-induced AP-1 activation. Collectively, our results indicate that Ror2/Fz receptor complex plays an important role in the Wnt5a/Rac1/AP-1 pathway by regulating the polymerization of Dvl."xsd:string |
| http://purl.uniprot.org/citations/20457807 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00177-10"xsd:string |
| http://purl.uniprot.org/citations/20457807 | http://purl.uniprot.org/core/author | "Endo M."xsd:string |
| http://purl.uniprot.org/citations/20457807 | http://purl.uniprot.org/core/author | "Minami Y."xsd:string |
| http://purl.uniprot.org/citations/20457807 | http://purl.uniprot.org/core/author | "Nishita M."xsd:string |
| http://purl.uniprot.org/citations/20457807 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/20457807 | http://purl.uniprot.org/core/author | "Takada S."xsd:string |
| http://purl.uniprot.org/citations/20457807 | http://purl.uniprot.org/core/author | "Kikuchi A."xsd:string |
| http://purl.uniprot.org/citations/20457807 | http://purl.uniprot.org/core/author | "Qiao S."xsd:string |
| http://purl.uniprot.org/citations/20457807 | http://purl.uniprot.org/core/author | "Nomachi A."xsd:string |
| http://purl.uniprot.org/citations/20457807 | http://purl.uniprot.org/core/author | "Itsukushima S."xsd:string |
| http://purl.uniprot.org/citations/20457807 | http://purl.uniprot.org/core/author | "Inaba D."xsd:string |
| http://purl.uniprot.org/citations/20457807 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20457807 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/20457807 | http://purl.uniprot.org/core/pages | "3610-3619"xsd:string |
| http://purl.uniprot.org/citations/20457807 | http://purl.uniprot.org/core/title | "Ror2/Frizzled complex mediates Wnt5a-induced AP-1 activation by regulating Dishevelled polymerization."xsd:string |
| http://purl.uniprot.org/citations/20457807 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/20457807 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20457807 |
| http://purl.uniprot.org/citations/20457807 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20457807 |
| http://purl.uniprot.org/uniprot/#_E9PUN5-mappedCitation-20457807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20457807 |
| http://purl.uniprot.org/uniprot/#_P22725-mappedCitation-20457807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20457807 |
| http://purl.uniprot.org/uniprot/#_I6L9H1-mappedCitation-20457807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20457807 |
| http://purl.uniprot.org/uniprot/#_P41221-mappedCitation-20457807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20457807 |
| http://purl.uniprot.org/uniprot/#_Q3TZP9-mappedCitation-20457807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20457807 |