| http://purl.uniprot.org/citations/20462497 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20462497 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20462497 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-10R2 is a shared cell surface receptor required for the activation of five class 2 cytokines (IL-10, IL-22, IL-26, IL-28, and IL-29) that play critical roles in host defense. To define the molecular mechanisms that regulate its promiscuous binding, we have determined the crystal structure of the IL-10R2 ectodomain at 2.14 A resolution. IL-10R2 residues required for binding were identified by alanine scanning and used to derive computational models of IL-10/IL-10R1/IL-10R2 and IL-22/IL-22R1/IL-10R2 ternary complexes. The models reveal a conserved binding epitope that is surrounded by two clefts that accommodate the structural and chemical diversity of the cytokines. These results provide a structural framework for interpreting IL-10R2 single nucleotide polymorphisms associated with human disease."xsd:string |
| http://purl.uniprot.org/citations/20462497 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2010.02.009"xsd:string |
| http://purl.uniprot.org/citations/20462497 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2010.02.009"xsd:string |
| http://purl.uniprot.org/citations/20462497 | http://purl.uniprot.org/core/author | "Gao B."xsd:string |
| http://purl.uniprot.org/citations/20462497 | http://purl.uniprot.org/core/author | "Gao B."xsd:string |
| http://purl.uniprot.org/citations/20462497 | http://purl.uniprot.org/core/author | "Jones B.C."xsd:string |
| http://purl.uniprot.org/citations/20462497 | http://purl.uniprot.org/core/author | "Jones B.C."xsd:string |
| http://purl.uniprot.org/citations/20462497 | http://purl.uniprot.org/core/author | "Logsdon N.J."xsd:string |
| http://purl.uniprot.org/citations/20462497 | http://purl.uniprot.org/core/author | "Logsdon N.J."xsd:string |
| http://purl.uniprot.org/citations/20462497 | http://purl.uniprot.org/core/author | "Walter M.R."xsd:string |
| http://purl.uniprot.org/citations/20462497 | http://purl.uniprot.org/core/author | "Walter M.R."xsd:string |
| http://purl.uniprot.org/citations/20462497 | http://purl.uniprot.org/core/author | "Yoon S.I."xsd:string |
| http://purl.uniprot.org/citations/20462497 | http://purl.uniprot.org/core/author | "Yoon S.I."xsd:string |
| http://purl.uniprot.org/citations/20462497 | http://purl.uniprot.org/core/author | "Deshpande A."xsd:string |
| http://purl.uniprot.org/citations/20462497 | http://purl.uniprot.org/core/author | "Deshpande A."xsd:string |
| http://purl.uniprot.org/citations/20462497 | http://purl.uniprot.org/core/author | "Radaeva S."xsd:string |
| http://purl.uniprot.org/citations/20462497 | http://purl.uniprot.org/core/author | "Radaeva S."xsd:string |
| http://purl.uniprot.org/citations/20462497 | http://purl.uniprot.org/core/author | "Halloran B.A."xsd:string |
| http://purl.uniprot.org/citations/20462497 | http://purl.uniprot.org/core/author | "Halloran B.A."xsd:string |
| http://purl.uniprot.org/citations/20462497 | http://purl.uniprot.org/core/author | "Harris B.D."xsd:string |
| http://purl.uniprot.org/citations/20462497 | http://purl.uniprot.org/core/author | "Harris B.D."xsd:string |
| http://purl.uniprot.org/citations/20462497 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20462497 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |