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http://purl.uniprot.org/citations/20464982http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20464982http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To evaluate the role of human calcium-activated chloride channel 1 (hCLCA1) and mucin MUC5AC in allergic rhinitis.

Method

The expression of hCLCA1 and MUC5AC were determined by RT-PCR and immunohistochemical assay in nasal mucosa on 20 patients with allergic rhinitis and 7 normal persons.

Result

The expression of hCLCA1mRNA in allergic rhinitis group was positive, whereas in normal control group was absent (P<0.01). The expression of MUC5AC mRNA and MUC5AC protein in the allergic rhinitis group were higher than that in the control, respectively (both P<0.01). The increased expression of hCLCA1mRNA in allergic rhinitis group were well correlated with the expression of MUC5ACmRNA and MUC5AC protein and the correlation coefficients were 0.752 and 0.694(both P<0.05).

Conclusion

Upregulation of hCLCA1 mRNA expression may play a pivotal role in mucus overproduction in allergic rhinitis group. The inhibition of HCLCA1 expression may provide a new strategy for the treatment of allergic rhinitis."xsd:string
http://purl.uniprot.org/citations/20464982http://purl.uniprot.org/core/author"Wang L."xsd:string
http://purl.uniprot.org/citations/20464982http://purl.uniprot.org/core/author"Wu W."xsd:string
http://purl.uniprot.org/citations/20464982http://purl.uniprot.org/core/author"Cui Y."xsd:string
http://purl.uniprot.org/citations/20464982http://purl.uniprot.org/core/author"Chu H."xsd:string
http://purl.uniprot.org/citations/20464982http://purl.uniprot.org/core/author"Zhen H."xsd:string
http://purl.uniprot.org/citations/20464982http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20464982http://purl.uniprot.org/core/name"Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"xsd:string
http://purl.uniprot.org/citations/20464982http://purl.uniprot.org/core/pages"193-195"xsd:string
http://purl.uniprot.org/citations/20464982http://purl.uniprot.org/core/title"[Expression and clinical significance of calcium-activated chloride channel and mucins in nasal mucosa with allergic rhinitis]."xsd:string
http://purl.uniprot.org/citations/20464982http://purl.uniprot.org/core/volume"24"xsd:string
http://purl.uniprot.org/citations/20464982http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20464982
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