| http://purl.uniprot.org/citations/20465575 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20465575 | http://www.w3.org/2000/01/rdf-schema#comment | "Stimulation of naïve CD4(+) T cells through engagement of the T-cell receptor (TCR) and the CD28 co-receptor initiates cell proliferation which critically depends on interleukin (IL)-2 secretion and subsequent autocrine signalling via the IL-2 receptor. However, several studies indicate that in CD28-costimulated T cells additional IL-2-independent signals are also required for cell proliferation. In this study, using a neutralizing anti-human IL-2 antibody and two selective, structurally unrelated, cell-permeable I-κB kinase (IKK) inhibitors, BMS-345541 and PS-1145, we show that in human naïve CD4(+) T cells stimulated through a short engagement of the TCR and the CD28 co-receptor, IKK controls the expression of the cell cycle regulatory proteins cyclin D3, cyclin E and cyclin-dependent kinase 2 (CDK2) and the stability of the F-box protein S-phase kinase-associated protein 2 (SKP2) and its co-factor CDC28 protein kinase regulatory subunit 1B (CKS1B), through IL-2-independent mechanisms."xsd:string |
| http://purl.uniprot.org/citations/20465575 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2567.2010.03297.x"xsd:string |
| http://purl.uniprot.org/citations/20465575 | http://purl.uniprot.org/core/author | "Piccinini M."xsd:string |
| http://purl.uniprot.org/citations/20465575 | http://purl.uniprot.org/core/author | "De Marco G."xsd:string |
| http://purl.uniprot.org/citations/20465575 | http://purl.uniprot.org/core/author | "Rinaudo M.T."xsd:string |
| http://purl.uniprot.org/citations/20465575 | http://purl.uniprot.org/core/author | "Tovo P.A."xsd:string |
| http://purl.uniprot.org/citations/20465575 | http://purl.uniprot.org/core/author | "Ricotti E."xsd:string |
| http://purl.uniprot.org/citations/20465575 | http://purl.uniprot.org/core/author | "Buccinna B."xsd:string |
| http://purl.uniprot.org/citations/20465575 | http://purl.uniprot.org/core/author | "Lupino E."xsd:string |
| http://purl.uniprot.org/citations/20465575 | http://purl.uniprot.org/core/author | "Ramondetti C."xsd:string |
| http://purl.uniprot.org/citations/20465575 | http://purl.uniprot.org/core/author | "Lomartire A."xsd:string |
| http://purl.uniprot.org/citations/20465575 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20465575 | http://purl.uniprot.org/core/name | "Immunology"xsd:string |
| http://purl.uniprot.org/citations/20465575 | http://purl.uniprot.org/core/pages | "231-241"xsd:string |
| http://purl.uniprot.org/citations/20465575 | http://purl.uniprot.org/core/title | "In CD28-costimulated human naive CD4+ T cells, I-kappaB kinase controls the expression of cell cycle regulatory proteins via interleukin-2-independent mechanisms."xsd:string |
| http://purl.uniprot.org/citations/20465575 | http://purl.uniprot.org/core/volume | "131"xsd:string |
| http://purl.uniprot.org/citations/20465575 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20465575 |
| http://purl.uniprot.org/citations/20465575 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20465575 |
| http://purl.uniprot.org/uniprot/#_B3KP19-mappedCitation-20465575 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20465575 |
| http://purl.uniprot.org/uniprot/#_B3KTY3-mappedCitation-20465575 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20465575 |
| http://purl.uniprot.org/uniprot/#_B4DDL9-mappedCitation-20465575 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20465575 |
| http://purl.uniprot.org/uniprot/#_B4DRB9-mappedCitation-20465575 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20465575 |
| http://purl.uniprot.org/uniprot/#_B4DHK6-mappedCitation-20465575 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20465575 |
| http://purl.uniprot.org/uniprot/#_D6R9R7-mappedCitation-20465575 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20465575 |