| http://purl.uniprot.org/citations/20466882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20466882 | http://www.w3.org/2000/01/rdf-schema#comment | "Proper coordination of cholesterol biosynthesis and trafficking is essential to human health. The sterol regulatory element-binding proteins (SREBPs) are key transcription regulators of genes involved in cholesterol biosynthesis and uptake. We show here that microRNAs (miR-33a/b) embedded within introns of the SREBP genes target the adenosine triphosphate-binding cassette transporter A1 (ABCA1), an important regulator of high-density lipoprotein (HDL) synthesis and reverse cholesterol transport, for posttranscriptional repression. Antisense inhibition of miR-33 in mouse and human cell lines causes up-regulation of ABCA1 expression and increased cholesterol efflux, and injection of mice on a western-type diet with locked nucleic acid-antisense oligonucleotides results in elevated plasma HDL. Our findings indicate that miR-33 acts in concert with the SREBP host genes to control cholesterol homeostasis and suggest that miR-33 may represent a therapeutic target for ameliorating cardiometabolic diseases."xsd:string |
| http://purl.uniprot.org/citations/20466882 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1189123"xsd:string |
| http://purl.uniprot.org/citations/20466882 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/20466882 | http://purl.uniprot.org/core/author | "Shioda T."xsd:string |
| http://purl.uniprot.org/citations/20466882 | http://purl.uniprot.org/core/author | "Cohen D.E."xsd:string |
| http://purl.uniprot.org/citations/20466882 | http://purl.uniprot.org/core/author | "Gerszten R.E."xsd:string |
| http://purl.uniprot.org/citations/20466882 | http://purl.uniprot.org/core/author | "Naar A.M."xsd:string |
| http://purl.uniprot.org/citations/20466882 | http://purl.uniprot.org/core/author | "Kristo F."xsd:string |
| http://purl.uniprot.org/citations/20466882 | http://purl.uniprot.org/core/author | "Najafi-Shoushtari S.H."xsd:string |
| http://purl.uniprot.org/citations/20466882 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20466882 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/20466882 | http://purl.uniprot.org/core/pages | "1566-1569"xsd:string |
| http://purl.uniprot.org/citations/20466882 | http://purl.uniprot.org/core/title | "MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis."xsd:string |
| http://purl.uniprot.org/citations/20466882 | http://purl.uniprot.org/core/volume | "328"xsd:string |
| http://purl.uniprot.org/citations/20466882 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20466882 |
| http://purl.uniprot.org/citations/20466882 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20466882 |
| http://purl.uniprot.org/uniprot/Q3U1N2#attribution-C59A3608FB85E69CA57C94184D380546 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20466882 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VH82-mappedCitation-20466882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20466882 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VHQ9-mappedCitation-20466882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20466882 |
| http://purl.uniprot.org/uniprot/#_B4DGV9-mappedCitation-20466882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20466882 |
| http://purl.uniprot.org/uniprot/#_B4DSU0-mappedCitation-20466882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20466882 |
| http://purl.uniprot.org/uniprot/#_A8MTU8-mappedCitation-20466882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20466882 |
| http://purl.uniprot.org/uniprot/#_B3KR77-mappedCitation-20466882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20466882 |
| http://purl.uniprot.org/uniprot/#_B3KXZ7-mappedCitation-20466882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20466882 |