| http://purl.uniprot.org/citations/20466885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20466885 | http://www.w3.org/2000/01/rdf-schema#comment | "Cholesterol metabolism is tightly regulated at the cellular level. Here we show that miR-33, an intronic microRNA (miRNA) located within the gene encoding sterol-regulatory element-binding factor-2 (SREBF-2), a transcriptional regulator of cholesterol synthesis, modulates the expression of genes involved in cellular cholesterol transport. In mouse and human cells, miR-33 inhibits the expression of the adenosine triphosphate-binding cassette (ABC) transporter, ABCA1, thereby attenuating cholesterol efflux to apolipoprotein A1. In mouse macrophages, miR-33 also targets ABCG1, reducing cholesterol efflux to nascent high-density lipoprotein (HDL). Lentiviral delivery of miR-33 to mice represses ABCA1 expression in the liver, reducing circulating HDL levels. Conversely, silencing of miR-33 in vivo increases hepatic expression of ABCA1 and plasma HDL levels. Thus, miR-33 appears to regulate both HDL biogenesis in the liver and cellular cholesterol efflux."xsd:string |
| http://purl.uniprot.org/citations/20466885 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1189862"xsd:string |
| http://purl.uniprot.org/citations/20466885 | http://purl.uniprot.org/core/author | "Moore K.J."xsd:string |
| http://purl.uniprot.org/citations/20466885 | http://purl.uniprot.org/core/author | "Fitzgerald M.L."xsd:string |
| http://purl.uniprot.org/citations/20466885 | http://purl.uniprot.org/core/author | "Davalos A."xsd:string |
| http://purl.uniprot.org/citations/20466885 | http://purl.uniprot.org/core/author | "Fisher E.A."xsd:string |
| http://purl.uniprot.org/citations/20466885 | http://purl.uniprot.org/core/author | "Rayner K.J."xsd:string |
| http://purl.uniprot.org/citations/20466885 | http://purl.uniprot.org/core/author | "Tamehiro N."xsd:string |
| http://purl.uniprot.org/citations/20466885 | http://purl.uniprot.org/core/author | "Fernandez-Hernando C."xsd:string |
| http://purl.uniprot.org/citations/20466885 | http://purl.uniprot.org/core/author | "Parathath S."xsd:string |
| http://purl.uniprot.org/citations/20466885 | http://purl.uniprot.org/core/author | "Suarez Y."xsd:string |
| http://purl.uniprot.org/citations/20466885 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20466885 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/20466885 | http://purl.uniprot.org/core/pages | "1570-1573"xsd:string |
| http://purl.uniprot.org/citations/20466885 | http://purl.uniprot.org/core/title | "MiR-33 contributes to the regulation of cholesterol homeostasis."xsd:string |
| http://purl.uniprot.org/citations/20466885 | http://purl.uniprot.org/core/volume | "328"xsd:string |
| http://purl.uniprot.org/citations/20466885 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20466885 |
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| http://purl.uniprot.org/uniprot/#_Q3U8R7-mappedCitation-20466885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20466885 |
| http://purl.uniprot.org/uniprot/#_Q8CAV5-mappedCitation-20466885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20466885 |
| http://purl.uniprot.org/uniprot/#_Q3TDD1-mappedCitation-20466885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20466885 |
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