| http://purl.uniprot.org/citations/20467816 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20467816 | http://www.w3.org/2000/01/rdf-schema#comment | "One main feature of apoptosis is the sequential degradation of the nuclear structure, including the fragmentation of chromatin and caspase-mediated cleavage of various nuclear proteins. Among these proteins is the Nuclear Mitotic Apparatus protein (NuMA) which plays a specific role in the organization of the mitotic spindle. The exact function of NuMA in the interphase nucleus is unknown, but a number of reports have suggested that it may play a role in chromatin organization and/or gene expression. Here we show that upon cleavage in apoptotic cells, the N-terminal cleavage fragment of NuMA is solubilized while the C-terminal fragment remains associated with the condensed chromatin. Using pancaspase inhibitor z-VAD-fmk and caspase-3 deficient MCF-7 cells, we further show that the solubilization is dependent on caspase-mediated cleavage of NuMA. Finally, the silencing of NuMA by RNAi accelerated nuclear breakdown in apoptotic MCF-7 cells. These results suggest that NuMA may provide structural support in the interphase nucleus by contributing to the organization of chromatin."xsd:string |
| http://purl.uniprot.org/citations/20467816 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10495-010-0506-8"xsd:string |
| http://purl.uniprot.org/citations/20467816 | http://purl.uniprot.org/core/author | "Kivinen K."xsd:string |
| http://purl.uniprot.org/citations/20467816 | http://purl.uniprot.org/core/author | "Kallajoki M."xsd:string |
| http://purl.uniprot.org/citations/20467816 | http://purl.uniprot.org/core/author | "Taimen P."xsd:string |
| http://purl.uniprot.org/citations/20467816 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20467816 | http://purl.uniprot.org/core/name | "Apoptosis"xsd:string |
| http://purl.uniprot.org/citations/20467816 | http://purl.uniprot.org/core/pages | "936-945"xsd:string |
| http://purl.uniprot.org/citations/20467816 | http://purl.uniprot.org/core/title | "Silencing of Nuclear Mitotic Apparatus protein (NuMA) accelerates the apoptotic disintegration of the nucleus."xsd:string |
| http://purl.uniprot.org/citations/20467816 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/20467816 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20467816 |
| http://purl.uniprot.org/citations/20467816 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20467816 |
| http://purl.uniprot.org/uniprot/#_A8K394-mappedCitation-20467816 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20467816 |
| http://purl.uniprot.org/uniprot/#_G1UI36-mappedCitation-20467816 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20467816 |
| http://purl.uniprot.org/uniprot/#_Q14980-mappedCitation-20467816 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20467816 |
| http://purl.uniprot.org/uniprot/#_Q7Z757-mappedCitation-20467816 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20467816 |
| http://purl.uniprot.org/uniprot/#_Q4LE64-mappedCitation-20467816 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20467816 |
| http://purl.uniprot.org/uniprot/#_Q59HB8-mappedCitation-20467816 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20467816 |
| http://purl.uniprot.org/uniprot/#_Q3SYK8-mappedCitation-20467816 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20467816 |
| http://purl.uniprot.org/uniprot/#_Q9UPG3-mappedCitation-20467816 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20467816 |
| http://purl.uniprot.org/uniprot/#_Q86XH4-mappedCitation-20467816 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20467816 |
| http://purl.uniprot.org/uniprot/#_Q9UNL7-mappedCitation-20467816 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20467816 |
| http://purl.uniprot.org/uniprot/#_Q96HN5-mappedCitation-20467816 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20467816 |
| http://purl.uniprot.org/uniprot/Q7Z757 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20467816 |