| http://purl.uniprot.org/citations/20471948 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20471948 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20471948 | http://www.w3.org/2000/01/rdf-schema#comment | "Recruitment of the P-TEFb kinase by HIV-1 Tat to the viral promoter triggers the phosphorylation and escape of RNA polymerase II from promoter-proximal pausing. It is unclear, however, if Tat recruits additional host factors that further stimulate HIV-1 transcription. Using a sequential affinity-purification scheme, we have identified human transcription factors/coactivators AFF4, ENL, AF9, and elongation factor ELL2 as components of the Tat-P-TEFb complex. Through the bridging functions of Tat and AFF4, P-TEFb and ELL2 combine to form a bifunctional elongation complex that greatly activates HIV-1 transcription. Without Tat, AFF4 can mediate the ELL2-P-TEFb interaction, albeit inefficiently. Tat overcomes this limitation by bringing more ELL2 to P-TEFb and stabilizing ELL2 in a process that requires active P-TEFb. The ability of Tat to enable two different classes of elongation factors to cooperate and coordinate their actions on the same polymerase enzyme explains why Tat is such a powerful activator of HIV-1 transcription."xsd:string |
| http://purl.uniprot.org/citations/20471948 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2010.04.013"xsd:string |
| http://purl.uniprot.org/citations/20471948 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2010.04.013"xsd:string |
| http://purl.uniprot.org/citations/20471948 | http://purl.uniprot.org/core/author | "He N."xsd:string |
| http://purl.uniprot.org/citations/20471948 | http://purl.uniprot.org/core/author | "He N."xsd:string |
| http://purl.uniprot.org/citations/20471948 | http://purl.uniprot.org/core/author | "Liu M."xsd:string |
| http://purl.uniprot.org/citations/20471948 | http://purl.uniprot.org/core/author | "Liu M."xsd:string |
| http://purl.uniprot.org/citations/20471948 | http://purl.uniprot.org/core/author | "Krogan N.J."xsd:string |
| http://purl.uniprot.org/citations/20471948 | http://purl.uniprot.org/core/author | "Krogan N.J."xsd:string |
| http://purl.uniprot.org/citations/20471948 | http://purl.uniprot.org/core/author | "Xue Y."xsd:string |
| http://purl.uniprot.org/citations/20471948 | http://purl.uniprot.org/core/author | "Xue Y."xsd:string |
| http://purl.uniprot.org/citations/20471948 | http://purl.uniprot.org/core/author | "Zhou Q."xsd:string |
| http://purl.uniprot.org/citations/20471948 | http://purl.uniprot.org/core/author | "Zhou Q."xsd:string |
| http://purl.uniprot.org/citations/20471948 | http://purl.uniprot.org/core/author | "Alber T."xsd:string |
| http://purl.uniprot.org/citations/20471948 | http://purl.uniprot.org/core/author | "Alber T."xsd:string |
| http://purl.uniprot.org/citations/20471948 | http://purl.uniprot.org/core/author | "Hsu J."xsd:string |
| http://purl.uniprot.org/citations/20471948 | http://purl.uniprot.org/core/author | "Hsu J."xsd:string |
| http://purl.uniprot.org/citations/20471948 | http://purl.uniprot.org/core/author | "Chou S."xsd:string |
| http://purl.uniprot.org/citations/20471948 | http://purl.uniprot.org/core/author | "Chou S."xsd:string |
| http://purl.uniprot.org/citations/20471948 | http://purl.uniprot.org/core/author | "Burlingame A."xsd:string |
| http://purl.uniprot.org/citations/20471948 | http://purl.uniprot.org/core/author | "Burlingame A."xsd:string |
| http://purl.uniprot.org/citations/20471948 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20471948 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |