| http://purl.uniprot.org/citations/20483722 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20483722 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent studies have suggested that TLR9 signaling in early endosomes leads to IFN-alpha production by plasmacytoid dendritic cells (pDCs), whereas TLR9 signaling in late endosomes induces pDC maturation, IL-6, and TNF-alpha secretion. In this study, we show that human DNA as well as CpG-oligodeoxynucleotides (ODNs) in complex with heat shock protein 90 (Hsp90) stimulate pDCs to produce large quantities of IFN-alpha. The Hsp90-CpG-A complexes are targeted into the Rab5+, early endosomal Ag 1+-static early endosome postinternalization by DCs, suggesting that preferential sorting of Hsp90-chaperoned self-DNA/CpG-ODNs to the static endosome is required for signaling through TLR9 for IFN-alpha production. Interestingly, Hsp90-mediated preferential static early endosomal translocation of CpG-ODNs triggers robust IFN-alpha production from murine conventional DCs. Thus, extracellular Hsp90 converts inert self-DNA/CpG-ODNs into a potent trigger of IFN-alpha production via spatiotemporal regulation."xsd:string |
| http://purl.uniprot.org/citations/20483722 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1000490"xsd:string |
| http://purl.uniprot.org/citations/20483722 | http://purl.uniprot.org/core/author | "Sato N."xsd:string |
| http://purl.uniprot.org/citations/20483722 | http://purl.uniprot.org/core/author | "Saito K."xsd:string |
| http://purl.uniprot.org/citations/20483722 | http://purl.uniprot.org/core/author | "Hirata K."xsd:string |
| http://purl.uniprot.org/citations/20483722 | http://purl.uniprot.org/core/author | "Tamura Y."xsd:string |
| http://purl.uniprot.org/citations/20483722 | http://purl.uniprot.org/core/author | "Okuya K."xsd:string |
| http://purl.uniprot.org/citations/20483722 | http://purl.uniprot.org/core/author | "Torigoe T."xsd:string |
| http://purl.uniprot.org/citations/20483722 | http://purl.uniprot.org/core/author | "Kutomi G."xsd:string |
| http://purl.uniprot.org/citations/20483722 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20483722 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/20483722 | http://purl.uniprot.org/core/pages | "7092-7099"xsd:string |
| http://purl.uniprot.org/citations/20483722 | http://purl.uniprot.org/core/title | "Spatiotemporal regulation of heat shock protein 90-chaperoned self-DNA and CpG-oligodeoxynucleotide for type I IFN induction via targeting to static early endosome."xsd:string |
| http://purl.uniprot.org/citations/20483722 | http://purl.uniprot.org/core/volume | "184"xsd:string |
| http://purl.uniprot.org/citations/20483722 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20483722 |
| http://purl.uniprot.org/citations/20483722 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20483722 |
| http://purl.uniprot.org/uniprot/#_Q9EQU3-mappedCitation-20483722 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20483722 |
| http://purl.uniprot.org/uniprot/Q9EQU3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20483722 |