| http://purl.uniprot.org/citations/20483761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20483761 | http://www.w3.org/2000/01/rdf-schema#comment | "Medullary thymic epithelial cells expressing the Aire gene play a critical role in the induction of tolerance to tissue-specific Ags (TSAs). It was postulated that recognition of Aire-controlled TSAs by immature thymocytes results in the selection of natural CD4+Foxp3+ regulatory T cells (Tregs) and enriches this repertoire in self-reactive receptors, contributing to its vast diversity. In this study, we compared the TCRs on individual Tregs in Aire+ and Aire-mice expressing a miniature TCR repertoire (TCRmini) along with GFP driven by the Foxp3 promoter (Foxp3GFP). The Treg TCR repertoires in Aire+ and Aire-TCRminiFoxp3GFP mice were similar and more diverse than their repertoires on CD4+ Foxp3-thymocytes. Further, TCRs found on potentially self-reactive T cells, with an activated phenotype (CD4+Foxp3-CD62Llow) in Aire-TCRminiFoxp3GFP mice, appear distinct from TCRs found on Tregs in Aire+ TCRminiFoxp3GFP mice. Lastly, we found no evidence that TSAs presented by medullary thymic epithelial cells in Aire+TCRmini mice are often recognized as agonists by Treg-derived TCR hybridomas or CD4+CD25+ thymocytes, containing both natural Tregs and precursors. Thus, positive selection and self-reactivity of the global Treg repertoire are not controlled by Aire-dependent TSAs."xsd:string |
| http://purl.uniprot.org/citations/20483761 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0903609"xsd:string |
| http://purl.uniprot.org/citations/20483761 | http://purl.uniprot.org/core/author | "Kern J."xsd:string |
| http://purl.uniprot.org/citations/20483761 | http://purl.uniprot.org/core/author | "Ignatowicz L."xsd:string |
| http://purl.uniprot.org/citations/20483761 | http://purl.uniprot.org/core/author | "Cebula A."xsd:string |
| http://purl.uniprot.org/citations/20483761 | http://purl.uniprot.org/core/author | "Daniely D."xsd:string |
| http://purl.uniprot.org/citations/20483761 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20483761 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/20483761 | http://purl.uniprot.org/core/pages | "6865-6873"xsd:string |
| http://purl.uniprot.org/citations/20483761 | http://purl.uniprot.org/core/title | "Diversity of TCRs on natural Foxp3+ T cells in mice lacking Aire expression."xsd:string |
| http://purl.uniprot.org/citations/20483761 | http://purl.uniprot.org/core/volume | "184"xsd:string |
| http://purl.uniprot.org/citations/20483761 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20483761 |
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