| http://purl.uniprot.org/citations/20483763 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20483763 | http://www.w3.org/2000/01/rdf-schema#comment | "The expression of pathogen recognition receptors in human FOXP3+ T regulatory cells is established, yet the function of these receptors is currently obscure. In the process of studying the function of both peripheral and lamina propria FOXP3+ lymphocytes in patients with the human inflammatory bowel disease Crohn's disease, we observed a clear deficiency in the quantity of FOXP3+ lymphocytes in patients with disease-associated polymorphisms in the pathogen recognition receptor gene NOD2. Subsequently, we determined that the NOD2 ligand, muramyl dipeptide (MDP), activates NF-kappaB in primary human FOXP3+ T cells. This activation is functionally relevant, as MDP-stimulated human FOXP3+ T cells are protected from death receptor Fas-mediated apoptosis. Importantly, apoptosis protection was not evident in MDP-stimulated FOXP3+ T cells isolated from a patient with the disease-associated polymorphism. Thus, we propose that one function of pathogen recognition receptors in human T regulatory cells is the protection against death receptor-mediated apoptosis in a Fas ligand-rich environment, such as that of the inflamed intestinal subepithelial space."xsd:string |
| http://purl.uniprot.org/citations/20483763 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0901479"xsd:string |
| http://purl.uniprot.org/citations/20483763 | http://purl.uniprot.org/core/author | "Xiong Y."xsd:string |
| http://purl.uniprot.org/citations/20483763 | http://purl.uniprot.org/core/author | "Tung J."xsd:string |
| http://purl.uniprot.org/citations/20483763 | http://purl.uniprot.org/core/author | "Bell M.P."xsd:string |
| http://purl.uniprot.org/citations/20483763 | http://purl.uniprot.org/core/author | "Svingen P.A."xsd:string |
| http://purl.uniprot.org/citations/20483763 | http://purl.uniprot.org/core/author | "Smyrk T."xsd:string |
| http://purl.uniprot.org/citations/20483763 | http://purl.uniprot.org/core/author | "Rahman M.K."xsd:string |
| http://purl.uniprot.org/citations/20483763 | http://purl.uniprot.org/core/author | "Egan L.J."xsd:string |
| http://purl.uniprot.org/citations/20483763 | http://purl.uniprot.org/core/author | "Faubion W.A. Jr."xsd:string |
| http://purl.uniprot.org/citations/20483763 | http://purl.uniprot.org/core/author | "Midtling E.H."xsd:string |
| http://purl.uniprot.org/citations/20483763 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20483763 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/20483763 | http://purl.uniprot.org/core/pages | "7247-7256"xsd:string |
| http://purl.uniprot.org/citations/20483763 | http://purl.uniprot.org/core/title | "The pathogen recognition receptor NOD2 regulates human FOXP3+ T cell survival."xsd:string |
| http://purl.uniprot.org/citations/20483763 | http://purl.uniprot.org/core/volume | "184"xsd:string |
| http://purl.uniprot.org/citations/20483763 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20483763 |
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