| http://purl.uniprot.org/citations/20484821 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20484821 | http://www.w3.org/2000/01/rdf-schema#comment | "Heterozygous mutations of GATA3, which encodes a dual zinc-finger transcription factor, cause hypoparathyroidism with sensorineural deafness and renal dysplasia. Here, we have investigated the role of GATA3 in parathyroid function by challenging Gata3+/-mice with a diet low in calcium and vitamin D so as to expose any defects in parathyroid function. This led to a higher mortality among Gata3+/-mice compared with Gata3+/+ mice. Compared with their wild-type littermates, Gata3+/-mice had lower plasma concentrations of calcium and parathyroid hormone (PTH) and smaller parathyroid glands with a reduced Ki-67 proliferation rate. At E11.5, Gata3+/-embryos had smaller parathyroid-thymus primordia with fewer cells expressing the parathyroid-specific gene glial cells missing 2 (Gcm2), the homolog of human GCMB. In contrast, E11.5 Gata3-/-embryos had no Gcm2 expression and by E12.5 had gross defects in the third and fourth pharyngeal pouches, including absent parathyroid-thymus primordia. Electrophoretic mobility shift, luciferase reporter, and chromatin immunoprecipitation assays showed that GATA3 binds specifically to a functional double-GATA motif within the GCMB promoter. Thus, GATA3 is critical for the differentiation and survival of parathyroid progenitor cells and, with GCM2/B, forms part of a transcriptional cascade in parathyroid development and function."xsd:string |
| http://purl.uniprot.org/citations/20484821 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci42021"xsd:string |
| http://purl.uniprot.org/citations/20484821 | http://purl.uniprot.org/core/author | "Ali A."xsd:string |
| http://purl.uniprot.org/citations/20484821 | http://purl.uniprot.org/core/author | "Wei Q."xsd:string |
| http://purl.uniprot.org/citations/20484821 | http://purl.uniprot.org/core/author | "Stacey J.M."xsd:string |
| http://purl.uniprot.org/citations/20484821 | http://purl.uniprot.org/core/author | "Grosveld F."xsd:string |
| http://purl.uniprot.org/citations/20484821 | http://purl.uniprot.org/core/author | "Hough T."xsd:string |
| http://purl.uniprot.org/citations/20484821 | http://purl.uniprot.org/core/author | "Nesbit M.A."xsd:string |
| http://purl.uniprot.org/citations/20484821 | http://purl.uniprot.org/core/author | "Thakker R.V."xsd:string |
| http://purl.uniprot.org/citations/20484821 | http://purl.uniprot.org/core/author | "Fairclough R.J."xsd:string |
| http://purl.uniprot.org/citations/20484821 | http://purl.uniprot.org/core/author | "Grigorieva E.F."xsd:string |
| http://purl.uniprot.org/citations/20484821 | http://purl.uniprot.org/core/author | "Grigorieva I.V."xsd:string |
| http://purl.uniprot.org/citations/20484821 | http://purl.uniprot.org/core/author | "Condie B.G."xsd:string |
| http://purl.uniprot.org/citations/20484821 | http://purl.uniprot.org/core/author | "Kurek D."xsd:string |
| http://purl.uniprot.org/citations/20484821 | http://purl.uniprot.org/core/author | "Fraser W.D."xsd:string |
| http://purl.uniprot.org/citations/20484821 | http://purl.uniprot.org/core/author | "Manley N."xsd:string |
| http://purl.uniprot.org/citations/20484821 | http://purl.uniprot.org/core/author | "Gaynor K.U."xsd:string |
| http://purl.uniprot.org/citations/20484821 | http://purl.uniprot.org/core/author | "Mihai R."xsd:string |
| http://purl.uniprot.org/citations/20484821 | http://purl.uniprot.org/core/author | "Mirczuk S."xsd:string |
| http://purl.uniprot.org/citations/20484821 | http://purl.uniprot.org/core/author | "Stechman M.J."xsd:string |
| http://purl.uniprot.org/citations/20484821 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20484821 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/20484821 | http://purl.uniprot.org/core/pages | "2144-2155"xsd:string |
| http://purl.uniprot.org/citations/20484821 | http://purl.uniprot.org/core/title | "Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2."xsd:string |