| http://purl.uniprot.org/citations/20493731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20493731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20493731 | http://www.w3.org/2000/01/rdf-schema#comment | "Dectin-2 (gene symbol Clec4n) is a C-type lectin expressed by dendritic cells (DCs) and macrophages. However, its functional roles and signaling mechanisms remain to be elucidated. Here, we generated Clec4n(-/-) mice and showed that this molecule is important for host defense against Candida albicans (C. albicans). Clec4n(-/-) DCs had virtually no fungal alpha-mannan-induced cytokine production. Dectin-2 signaling induced cytokines through an FcRgamma chain and Syk-CARD9-NF-kappaB-dependent signaling pathway without involvement of MAP kinases. The yeast form of C. albicans induced interleukin-1beta (IL-1beta) and IL-23 secretion in a Dectin-2-dependent manner. In contrast, cytokine production induced by the hyphal form was only partially dependent on this lectin. Both yeast and hyphae induced Th17 cell differentiation, in which Dectin-2, but not Dectin-1, was mainly involved. Because IL-17A-deficient mice were highly susceptible to systemic candida infection, this study suggests that Dectin-2 is important in host defense against C. albicans by inducing Th17 cell differentiation."xsd:string |
| http://purl.uniprot.org/citations/20493731 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2010.05.001"xsd:string |
| http://purl.uniprot.org/citations/20493731 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2010.05.001"xsd:string |
| http://purl.uniprot.org/citations/20493731 | http://purl.uniprot.org/core/author | "Kubo S."xsd:string |
| http://purl.uniprot.org/citations/20493731 | http://purl.uniprot.org/core/author | "Kubo S."xsd:string |
| http://purl.uniprot.org/citations/20493731 | http://purl.uniprot.org/core/author | "Shibuya K."xsd:string |
| http://purl.uniprot.org/citations/20493731 | http://purl.uniprot.org/core/author | "Shibuya K."xsd:string |
| http://purl.uniprot.org/citations/20493731 | http://purl.uniprot.org/core/author | "Saito T."xsd:string |
| http://purl.uniprot.org/citations/20493731 | http://purl.uniprot.org/core/author | "Saito T."xsd:string |
| http://purl.uniprot.org/citations/20493731 | http://purl.uniprot.org/core/author | "Yamamoto N."xsd:string |
| http://purl.uniprot.org/citations/20493731 | http://purl.uniprot.org/core/author | "Yamamoto N."xsd:string |
| http://purl.uniprot.org/citations/20493731 | http://purl.uniprot.org/core/author | "Yamasaki S."xsd:string |
| http://purl.uniprot.org/citations/20493731 | http://purl.uniprot.org/core/author | "Yamasaki S."xsd:string |
| http://purl.uniprot.org/citations/20493731 | http://purl.uniprot.org/core/author | "Chung S.H."xsd:string |
| http://purl.uniprot.org/citations/20493731 | http://purl.uniprot.org/core/author | "Chung S.H."xsd:string |
| http://purl.uniprot.org/citations/20493731 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/20493731 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/20493731 | http://purl.uniprot.org/core/author | "Adachi Y."xsd:string |
| http://purl.uniprot.org/citations/20493731 | http://purl.uniprot.org/core/author | "Adachi Y."xsd:string |
| http://purl.uniprot.org/citations/20493731 | http://purl.uniprot.org/core/author | "Saijo S."xsd:string |
| http://purl.uniprot.org/citations/20493731 | http://purl.uniprot.org/core/author | "Saijo S."xsd:string |
| http://purl.uniprot.org/citations/20493731 | http://purl.uniprot.org/core/author | "Yamabe K."xsd:string |
| http://purl.uniprot.org/citations/20493731 | http://purl.uniprot.org/core/author | "Yamabe K."xsd:string |