| http://purl.uniprot.org/citations/20493808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20493808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20493808 | http://www.w3.org/2000/01/rdf-schema#comment | "Ras was found to regulate Dictyostelium chemotaxis, but the mechanisms that spatially and temporally control Ras activity during chemotaxis remain largely unknown. We report the discovery of a Ras signaling complex that includes the Ras guanine exchange factor (RasGEF) Aimless, RasGEFH, protein phosphatase 2A (PP2A), and a scaffold designated Sca1. The Sca1/RasGEF/PP2A complex is recruited to the plasma membrane in a chemoattractant- and F-actin-dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of RasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. In addition, PKB and PKB-related PKBR1 phosphorylate Sca1 and regulate the membrane localization of the Sca1/RasGEF/PP2A complex, and thereby RasC activity, in a negative feedback fashion. Thus, our study uncovered a molecular mechanism whereby RasC activity and the spatiotemporal activation of TORC2 are tightly controlled at the leading edge of chemotaxing cells."xsd:string |
| http://purl.uniprot.org/citations/20493808 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2010.03.017"xsd:string |
| http://purl.uniprot.org/citations/20493808 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2010.03.017"xsd:string |
| http://purl.uniprot.org/citations/20493808 | http://purl.uniprot.org/core/author | "Briggs S.P."xsd:string |
| http://purl.uniprot.org/citations/20493808 | http://purl.uniprot.org/core/author | "Briggs S.P."xsd:string |
| http://purl.uniprot.org/citations/20493808 | http://purl.uniprot.org/core/author | "Charest P.G."xsd:string |
| http://purl.uniprot.org/citations/20493808 | http://purl.uniprot.org/core/author | "Charest P.G."xsd:string |
| http://purl.uniprot.org/citations/20493808 | http://purl.uniprot.org/core/author | "Firtel R.A."xsd:string |
| http://purl.uniprot.org/citations/20493808 | http://purl.uniprot.org/core/author | "Firtel R.A."xsd:string |
| http://purl.uniprot.org/citations/20493808 | http://purl.uniprot.org/core/author | "Lakoduk A."xsd:string |
| http://purl.uniprot.org/citations/20493808 | http://purl.uniprot.org/core/author | "Lakoduk A."xsd:string |
| http://purl.uniprot.org/citations/20493808 | http://purl.uniprot.org/core/author | "Sasaki A.T."xsd:string |
| http://purl.uniprot.org/citations/20493808 | http://purl.uniprot.org/core/author | "Sasaki A.T."xsd:string |
| http://purl.uniprot.org/citations/20493808 | http://purl.uniprot.org/core/author | "Shen Z."xsd:string |
| http://purl.uniprot.org/citations/20493808 | http://purl.uniprot.org/core/author | "Shen Z."xsd:string |
| http://purl.uniprot.org/citations/20493808 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20493808 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20493808 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/20493808 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/20493808 | http://purl.uniprot.org/core/pages | "737-749"xsd:string |
| http://purl.uniprot.org/citations/20493808 | http://purl.uniprot.org/core/pages | "737-749"xsd:string |
| http://purl.uniprot.org/citations/20493808 | http://purl.uniprot.org/core/title | "A Ras signaling complex controls the RasC-TORC2 pathway and directed cell migration."xsd:string |
| http://purl.uniprot.org/citations/20493808 | http://purl.uniprot.org/core/title | "A Ras signaling complex controls the RasC-TORC2 pathway and directed cell migration."xsd:string |