| http://purl.uniprot.org/citations/20494340 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20494340 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-5 is a pleiotropic cytokine that promotes eosinophil differentiation and survival. While naïve bronchial epithelial cells (BEC) produce low levels of IL-5, the role of BEC-derived IL-5 in allergic airway inflammation is unknown. We now show that BEC, isolated from mice with OVA-induced allergic airway disease (AAD), produced elevated levels of IL-5 mRNA and protein as compared to BEC from naïve mice. To determine the contribution of BEC-derived IL-5 to effector responses in the airways, IL-5 deficient bone marrow chimeric mice were generated in which IL-5 expression was restricted to stromal (e.g. BEC) or hematopoietic cells. When subjected to AAD, IL-5 produced by BECs contributed to mucous metaplasia, airway eosinophilia, and OVA-specific IgA levels. Thus, IL-5 production by BEC can impact the microenvironment of the lung, modifying pathologic and protective immune responses in the airways."xsd:string |
| http://purl.uniprot.org/citations/20494340 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellimm.2010.04.008"xsd:string |
| http://purl.uniprot.org/citations/20494340 | http://purl.uniprot.org/core/author | "Zhu L."xsd:string |
| http://purl.uniprot.org/citations/20494340 | http://purl.uniprot.org/core/author | "Wu C.A."xsd:string |
| http://purl.uniprot.org/citations/20494340 | http://purl.uniprot.org/core/author | "Puddington L."xsd:string |
| http://purl.uniprot.org/citations/20494340 | http://purl.uniprot.org/core/author | "Peluso J.J."xsd:string |
| http://purl.uniprot.org/citations/20494340 | http://purl.uniprot.org/core/author | "Lingenheld E.G."xsd:string |
| http://purl.uniprot.org/citations/20494340 | http://purl.uniprot.org/core/author | "Walker S.T."xsd:string |
| http://purl.uniprot.org/citations/20494340 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20494340 | http://purl.uniprot.org/core/name | "Cell Immunol"xsd:string |
| http://purl.uniprot.org/citations/20494340 | http://purl.uniprot.org/core/pages | "32-41"xsd:string |
| http://purl.uniprot.org/citations/20494340 | http://purl.uniprot.org/core/title | "Bronchial epithelial cells produce IL-5: implications for local immune responses in the airways."xsd:string |
| http://purl.uniprot.org/citations/20494340 | http://purl.uniprot.org/core/volume | "264"xsd:string |
| http://purl.uniprot.org/citations/20494340 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20494340 |
| http://purl.uniprot.org/citations/20494340 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20494340 |
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| http://purl.uniprot.org/uniprot/#_P04401-mappedCitation-20494340 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20494340 |
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| http://purl.uniprot.org/uniprot/Q62349 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20494340 |
| http://purl.uniprot.org/uniprot/P04401 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20494340 |
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