| http://purl.uniprot.org/citations/20495066 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20495066 | http://www.w3.org/2000/01/rdf-schema#comment | "B cell Ag receptors function in both signaling activation of Ag-specific cells and in collecting specific Ag for presentation to T lymphocytes. Signaling via PI3K is required for BCR-mediated activation and Ag presentation functions; however, the relevant downstream targets of PI3K in B cells are incompletely defined. In this study, we have investigated the roles of the PI3K effector molecule Bam32/DAPP1 in BCR signaling and BCR-mediated Ag presentation functions. In mouse primary B cells, Bam32 was required for efficient activation of the GTPase Rac1 and downstream signaling to JNK, but not activation of BLNK, phospholipase C gamma2, or calcium responses. Consistent with a role of this adaptor in Rac-mediated cytoskeletal rearrangement, Bam32 was required for BCR-induced cell adhesion and spreading responses on ICAM-1 or fibronectin-coated surfaces. The function of Bam32 in promoting Rac activation and adhesion required tyrosine 139, a known site of phosphorylation by Lyn kinase. After BCR crosslinking by Ag, Bam32-deficient B cells are able to carry out the initial steps of Ag endocytosis and processing, but show diminished ability to form Ag-specific conjugates with T cells and polarize F-actin at the B-T interface. As a result, Bam32-deficient B cells were unable to efficiently activate Ag-specific T cells. Together, these results indicate that Bam32 serves to integrate PI3K and Src kinase signaling to promote Rac-dependent B cell adhesive interactions important for Ag presentation function."xsd:string |
| http://purl.uniprot.org/citations/20495066 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0904176"xsd:string |
| http://purl.uniprot.org/citations/20495066 | http://purl.uniprot.org/core/author | "Hou S."xsd:string |
| http://purl.uniprot.org/citations/20495066 | http://purl.uniprot.org/core/author | "Zhang T.T."xsd:string |
| http://purl.uniprot.org/citations/20495066 | http://purl.uniprot.org/core/author | "Marshall A.J."xsd:string |
| http://purl.uniprot.org/citations/20495066 | http://purl.uniprot.org/core/author | "Al-Alwan M."xsd:string |
| http://purl.uniprot.org/citations/20495066 | http://purl.uniprot.org/core/author | "Makondo K."xsd:string |
| http://purl.uniprot.org/citations/20495066 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20495066 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/20495066 | http://purl.uniprot.org/core/pages | "6961-6969"xsd:string |
| http://purl.uniprot.org/citations/20495066 | http://purl.uniprot.org/core/title | "Bam32/DAPP1 promotes B cell adhesion and formation of polarized conjugates with T cells."xsd:string |
| http://purl.uniprot.org/citations/20495066 | http://purl.uniprot.org/core/volume | "184"xsd:string |
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