| http://purl.uniprot.org/citations/20496116 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20496116 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20496116 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent studies indicate that endocytosis of Eph-ephrin complexes may be one of the mechanisms by which a high affinity cell-cell adhesion is converted to a repulsive interaction. In this study, we show that EphA8 undergoes clathrin-mediated endocytosis upon treatment with ephrin-A5, and that EphA8 is associated tightly with Tiam-1, a Rac-specific guanine nucleotide exchange factor. Analysis of EphA8 deletion mutants revealed that a juxtamembrane region in EphA8 is critically involved in endocytosis of EphA8-ephrinA5 complexes. An EphA8 mutant lacking this juxtamembrane portion was defective for endocytosis with ephrinA5, and also displayed a weak association with Tiam-1. Expression of an endocytosis-defective version of EphA8 resulted in a low level of Rac activity in response to ephrin-A5 stimulation. More importantly, down-regulation of Tiam-1 resulted in inefficient endocytosis of EphA8-ephrinA5 complexes. These results suggest that Tiam-1 plays a role in clathrin-dependent endocytosis of EphA8-ephrinA5 complexes."xsd:string |
| http://purl.uniprot.org/citations/20496116 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10059-010-0075-2"xsd:string |
| http://purl.uniprot.org/citations/20496116 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10059-010-0075-2"xsd:string |
| http://purl.uniprot.org/citations/20496116 | http://purl.uniprot.org/core/author | "Park S."xsd:string |
| http://purl.uniprot.org/citations/20496116 | http://purl.uniprot.org/core/author | "Park S."xsd:string |
| http://purl.uniprot.org/citations/20496116 | http://purl.uniprot.org/core/author | "Shin J."xsd:string |
| http://purl.uniprot.org/citations/20496116 | http://purl.uniprot.org/core/author | "Shin J."xsd:string |
| http://purl.uniprot.org/citations/20496116 | http://purl.uniprot.org/core/author | "Yoo S."xsd:string |
| http://purl.uniprot.org/citations/20496116 | http://purl.uniprot.org/core/author | "Yoo S."xsd:string |
| http://purl.uniprot.org/citations/20496116 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20496116 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20496116 | http://purl.uniprot.org/core/name | "Mol. Cells"xsd:string |
| http://purl.uniprot.org/citations/20496116 | http://purl.uniprot.org/core/name | "Mol. Cells"xsd:string |
| http://purl.uniprot.org/citations/20496116 | http://purl.uniprot.org/core/pages | "603-609"xsd:string |
| http://purl.uniprot.org/citations/20496116 | http://purl.uniprot.org/core/pages | "603-609"xsd:string |
| http://purl.uniprot.org/citations/20496116 | http://purl.uniprot.org/core/title | "EphA8-ephrinA5 signaling and clathrin-mediated endocytosis is regulated by Tiam-1, a Rac-specific guanine nucleotide exchange factor."xsd:string |
| http://purl.uniprot.org/citations/20496116 | http://purl.uniprot.org/core/title | "EphA8-ephrinA5 signaling and clathrin-mediated endocytosis is regulated by Tiam-1, a Rac-specific guanine nucleotide exchange factor."xsd:string |
| http://purl.uniprot.org/citations/20496116 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/20496116 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/20496116 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20496116 |
| http://purl.uniprot.org/citations/20496116 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20496116 |
| http://purl.uniprot.org/citations/20496116 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20496116 |
| http://purl.uniprot.org/citations/20496116 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20496116 |