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| http://purl.uniprot.org/citations/20498629 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanisms of compromised mitochondrial function under various pathological conditions, including hypoxia, remain largely unknown. Recent studies have shown that microRNA-210 (miR-210) is induced by hypoxia under the regulation of hypoxia-inducible factor-1alpha and has an important role in cell survival under hypoxic microenvironment. Hence, we hypothesized that miR-210 has a role in regulating mitochondrial metabolism and investigated miR-210 effects on mitochondrial function in cancer cell lines under normal and hypoxic conditions. Our results demonstrate that miR-210 decreases mitochondrial function and upregulates the glycolysis, thus make cancer cells more sensitive to glycolysis inhibitor. miR-210 can also activate the generation of reactive oxygen species (ROS). ISCU (iron-sulfur cluster scaffold homolog) and COX10 (cytochrome c oxidase assembly protein), two important factors of the mitochondria electron transport chain and the tricarboxylic acid cycle have been identified as potential targets of miR-210. The unique means by which miR-210 regulates mitochondrial function reveals an miRNA-mediated link between microenvironmental stress, oxidative phosphorylation, ROS and iron homeostasis."xsd:string |
| http://purl.uniprot.org/citations/20498629 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2010.193"xsd:string |
| http://purl.uniprot.org/citations/20498629 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/20498629 | http://purl.uniprot.org/core/author | "Huang P."xsd:string |
| http://purl.uniprot.org/citations/20498629 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/20498629 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/20498629 | http://purl.uniprot.org/core/author | "Luthra R."xsd:string |
| http://purl.uniprot.org/citations/20498629 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20498629 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/20498629 | http://purl.uniprot.org/core/pages | "4362-4368"xsd:string |
| http://purl.uniprot.org/citations/20498629 | http://purl.uniprot.org/core/title | "Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression."xsd:string |
| http://purl.uniprot.org/citations/20498629 | http://purl.uniprot.org/core/volume | "29"xsd:string |
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