| http://purl.uniprot.org/citations/2049878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2049878 | http://www.w3.org/2000/01/rdf-schema#comment | "The uridine diphosphoglucose pyrophosphorylase (UDPGP1) gene of Dictyostelium discoideum is an excellent marker to study the pathways that control the expression of genes during development. We have previously shown that the UDPGP1 gene is regulated by exogenous cAMP acting on cell-surface cAMP receptors. Various steps in the signal transduction pathway between receptor stimulation and the induction of the gene can now be studied. Induction does not require the synthesis of intracellular cAMP, but does require new protein synthesis. By deletion and transformation with altered genes, two cis-acting sequences that are required for UDPGP1 expression have been identified. A GC-rich palindromic sequence located between -410 and -374 is essential for induction of the gene by extracellular cAMP, but not for its basal expression. A sequence element located between -374 and -337 is required for any basal expression of this gene. When the polarity of the palindromic sequence was reversed such that it resembled the H2K enhancer element, the gene could still be induced by exogenous cAMP. Two DNA binding activities were detected in gel mobility shift assays using a fragment containing both of the regulatory sequence elements of UDPGP1 gene. Transformation with a vector that resulted in the synthesis of anti-sense UDPGP1 RNA led to almost total elimination of the enzyme antigen and no detectable enzyme activity. However, these transformants developed normally, indicating that either UDPGP is not required for development or residual synthesis of UDPGP may be sufficient for normal development."xsd:string |
| http://purl.uniprot.org/citations/2049878 | http://purl.org/dc/terms/identifier | "doi:10.1002/dvg.1020120108"xsd:string |
| http://purl.uniprot.org/citations/2049878 | http://purl.uniprot.org/core/author | "Dottin R.P."xsd:string |
| http://purl.uniprot.org/citations/2049878 | http://purl.uniprot.org/core/author | "Haribabu B."xsd:string |
| http://purl.uniprot.org/citations/2049878 | http://purl.uniprot.org/core/author | "Moon B."xsd:string |
| http://purl.uniprot.org/citations/2049878 | http://purl.uniprot.org/core/author | "Pavlovic J."xsd:string |
| http://purl.uniprot.org/citations/2049878 | http://purl.uniprot.org/core/author | "Ortiz B.D."xsd:string |
| http://purl.uniprot.org/citations/2049878 | http://purl.uniprot.org/core/author | "Bodduluri S.R."xsd:string |
| http://purl.uniprot.org/citations/2049878 | http://purl.uniprot.org/core/author | "Doody J.F."xsd:string |
| http://purl.uniprot.org/citations/2049878 | http://purl.uniprot.org/core/author | "Mullings S."xsd:string |
| http://purl.uniprot.org/citations/2049878 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/2049878 | http://purl.uniprot.org/core/name | "Dev Genet"xsd:string |
| http://purl.uniprot.org/citations/2049878 | http://purl.uniprot.org/core/pages | "35-44"xsd:string |
| http://purl.uniprot.org/citations/2049878 | http://purl.uniprot.org/core/title | "Signal transduction pathways involved in the expression of the uridine diphosphoglucose pyrophosphorylase gene of Dictyostelium discoideum."xsd:string |
| http://purl.uniprot.org/citations/2049878 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/2049878 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2049878 |
| http://purl.uniprot.org/citations/2049878 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/2049878 |
| http://purl.uniprot.org/uniprot/#_P02886-mappedCitation-2049878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2049878 |
| http://purl.uniprot.org/uniprot/#_P04988-mappedCitation-2049878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2049878 |
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| http://purl.uniprot.org/uniprot/#_P54643-mappedCitation-2049878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2049878 |
| http://purl.uniprot.org/uniprot/P08800 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/2049878 |
| http://purl.uniprot.org/uniprot/P02886 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/2049878 |