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http://purl.uniprot.org/citations/20501509http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20501509http://www.w3.org/2000/01/rdf-schema#comment"

Aims

Monocyte systemic levels are known to be a major determinant of ischaemic tissue revascularization, but the mechanisms mediating mobilization of different monocyte subsets-Ly6C(hi) and Ly6C(lo)-to the blood and their respective role in post-ischaemic neovascularization are not clearly understood. Here, we hypothesized that distinct chemokine/chemokine receptor pathways, namely CCL2/CCR2, CX3CL1/CX3CR1, and CCL5/CCR5, differentially control monocyte subset systemic levels, and might thus impact post-ischaemic vessel growth.

Methods and results

In a model of murine hindlimb ischaemia, both Ly6C(hi) and Ly6C(lo) monocyte circulating levels were increased after femoral artery ligation. CCL2/CCR2 activation enhanced blood Ly6C(hi) and Ly6C(lo) monocyte counts, although the opposite effect was seen in mice with CCL2 or CCR2 deficiency. CX3CL1/CX3CR1 strongly impacted Ly6C(lo) monocyte levels, whereas CCL5/CCR5 had no role. Only CCL2/CCR2 signalling influenced neovascularization, which was increased in mice overexpressing CCL2, whereas it markedly decreased in CCL2-/-mice. Moreover, adoptive transfer of Ly6C(hi)-but not Ly6C(lo)-monocytes enhanced vessel growth and blood flow recovery.

Conclusion

Altogether, our data demonstrate that regulation of proangiogenic Ly6C(hi) monocytes systemic levels by CCL2/CCR2 controls post-ischaemic vessel growth, whereas Ly6C(lo) monocytes have no major role in this setting."xsd:string
http://purl.uniprot.org/citations/20501509http://purl.org/dc/terms/identifier"doi:10.1093/cvr/cvq153"xsd:string
http://purl.uniprot.org/citations/20501509http://purl.uniprot.org/core/author"Guerin C."xsd:string
http://purl.uniprot.org/citations/20501509http://purl.uniprot.org/core/author"Combadiere C."xsd:string
http://purl.uniprot.org/citations/20501509http://purl.uniprot.org/core/author"Rodero M.P."xsd:string
http://purl.uniprot.org/citations/20501509http://purl.uniprot.org/core/author"Cochain C."xsd:string
http://purl.uniprot.org/citations/20501509http://purl.uniprot.org/core/author"Duriez M."xsd:string
http://purl.uniprot.org/citations/20501509http://purl.uniprot.org/core/author"Levy B.I."xsd:string
http://purl.uniprot.org/citations/20501509http://purl.uniprot.org/core/author"Loinard C."xsd:string
http://purl.uniprot.org/citations/20501509http://purl.uniprot.org/core/author"Recalde A."xsd:string
http://purl.uniprot.org/citations/20501509http://purl.uniprot.org/core/author"Silvestre J.S."xsd:string
http://purl.uniprot.org/citations/20501509http://purl.uniprot.org/core/author"Vilar J."xsd:string
http://purl.uniprot.org/citations/20501509http://purl.uniprot.org/core/author"Zouggari Y."xsd:string
http://purl.uniprot.org/citations/20501509http://purl.uniprot.org/core/author"Mallat Z."xsd:string
http://purl.uniprot.org/citations/20501509http://purl.uniprot.org/core/author"Combadiere B."xsd:string
http://purl.uniprot.org/citations/20501509http://purl.uniprot.org/core/author"Poupel L."xsd:string
http://purl.uniprot.org/citations/20501509http://purl.uniprot.org/core/author"Richart A.L."xsd:string
http://purl.uniprot.org/citations/20501509http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20501509http://purl.uniprot.org/core/name"Cardiovasc Res"xsd:string
http://purl.uniprot.org/citations/20501509http://purl.uniprot.org/core/pages"186-195"xsd:string
http://purl.uniprot.org/citations/20501509http://purl.uniprot.org/core/title"Regulation of monocyte subset systemic levels by distinct chemokine receptors controls post-ischaemic neovascularization."xsd:string
http://purl.uniprot.org/citations/20501509http://purl.uniprot.org/core/volume"88"xsd:string
http://purl.uniprot.org/citations/20501509http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20501509
http://purl.uniprot.org/citations/20501509http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/20501509
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