| http://purl.uniprot.org/citations/20501595 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20501595 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20501595 | http://www.w3.org/2000/01/rdf-schema#comment | "The ancient origin of sleep is evidenced by deeply conserved signaling pathways regulating sleep-like behavior, such as signaling through the Epidermal growth factor receptor (EGFR). In Caenorhabditis elegans, a sleep-like state can be induced at any time during development or adulthood through conditional expression of LIN-3/EGF. The behavioral response to EGF is mediated by EGFR activity within a single cell, the ALA neuron, and mutations that impair ALA differentiation are expected to confer EGF-resistance. Here we describe three such EGF-resistant mutants. One of these corresponds to the LIM class homeodomain (HD) protein CEH-14/Lhx3, and the other two correspond to Paired-like HD proteins CEH-10/Chx10 and CEH-17/Phox2. Whereas CEH-14 is required for ALA-specific gene expression throughout development, the Prd-like proteins display complementary temporal contributions to gene expression, with the requirement for CEH-10 decreasing as that of CEH-17 increases. We present evidence that CEH-17 participates in a positive autoregulatory loop with CEH-14 in ALA, and that CEH-10, in addition to its role in ALA differentiation, functions in the generation of the ALA neuron. Similarly to CEH-17, CEH-10 is required for the posterior migration of the ALA axons, but CEH-14 appears to regulate an aspect of ALA axon outgrowth that is distinct from that of the Prd-like proteins. Our findings reveal partial modularity among the features of a neuronal differentiation program and their coordination by Prd and LIM class HD proteins."xsd:string |
| http://purl.uniprot.org/citations/20501595 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.040881"xsd:string |
| http://purl.uniprot.org/citations/20501595 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.040881"xsd:string |
| http://purl.uniprot.org/citations/20501595 | http://purl.uniprot.org/core/author | "Sternberg P.W."xsd:string |
| http://purl.uniprot.org/citations/20501595 | http://purl.uniprot.org/core/author | "Sternberg P.W."xsd:string |
| http://purl.uniprot.org/citations/20501595 | http://purl.uniprot.org/core/author | "Van Buskirk C."xsd:string |
| http://purl.uniprot.org/citations/20501595 | http://purl.uniprot.org/core/author | "Van Buskirk C."xsd:string |
| http://purl.uniprot.org/citations/20501595 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20501595 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20501595 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/20501595 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/20501595 | http://purl.uniprot.org/core/pages | "2065-2074"xsd:string |
| http://purl.uniprot.org/citations/20501595 | http://purl.uniprot.org/core/pages | "2065-2074"xsd:string |
| http://purl.uniprot.org/citations/20501595 | http://purl.uniprot.org/core/title | "Paired and LIM class homeodomain proteins coordinate differentiation of the C. elegans ALA neuron."xsd:string |
| http://purl.uniprot.org/citations/20501595 | http://purl.uniprot.org/core/title | "Paired and LIM class homeodomain proteins coordinate differentiation of the C. elegans ALA neuron."xsd:string |
| http://purl.uniprot.org/citations/20501595 | http://purl.uniprot.org/core/volume | "137"xsd:string |
| http://purl.uniprot.org/citations/20501595 | http://purl.uniprot.org/core/volume | "137"xsd:string |
| http://purl.uniprot.org/citations/20501595 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20501595 |
| http://purl.uniprot.org/citations/20501595 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20501595 |
| http://purl.uniprot.org/citations/20501595 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20501595 |
| http://purl.uniprot.org/citations/20501595 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20501595 |
| http://purl.uniprot.org/uniprot/P20271 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/20501595 |
| http://purl.uniprot.org/uniprot/G5EC89 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/20501595 |