| http://purl.uniprot.org/citations/20501656 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20501656 | http://www.w3.org/2000/01/rdf-schema#comment | "The Rho GTPase members and their effector proteins, such as the Wiskott-Aldrich syndrome protein (WASP), play critical roles in regulating actin dynamics that affect cell motility, endocytosis, cell division, and transport. It is well established that Caenorhabditis elegans wsp-1 plays an essential role in embryonic development. We were interested in the role of the C. elegans protein WSP-1 in the adult nematode. In this report, we show that a deletion mutant of wsp-1 exhibits a strong sensitivity to the neuromuscular inhibitor aldicarb. Transgenic rescue experiments demonstrated that neuronal expression of WSP-1 rescued this phenotype and that it required a functional WSP-1 Cdc42/Rac interactive binding domain. WSP-1-GFP fusion protein was found localized presynaptically, immediately adjacent to the synaptic protein RAB-3. Strong genetic interactions with wsp-1 and other genes involved in different stages of synaptic transmission were observed as the wsp-1(gm324) mutation suppresses the aldicarb resistance seen in unc-13(e51), unc-11(e47), and snt-1 (md290) mutants. These results provide genetic and pharmacological evidence that WSP-1 plays an essential role to stabilize the actin cytoskeleton at the neuronal active zone of the neuromuscular junction to restrain synaptic vesicle release."xsd:string |
| http://purl.uniprot.org/citations/20501656 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109.096164"xsd:string |
| http://purl.uniprot.org/citations/20501656 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/20501656 | http://purl.uniprot.org/core/author | "Kubiseski T.J."xsd:string |
| http://purl.uniprot.org/citations/20501656 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20501656 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/20501656 | http://purl.uniprot.org/core/pages | "23040-23046"xsd:string |
| http://purl.uniprot.org/citations/20501656 | http://purl.uniprot.org/core/title | "Caenorhabditis elegans wsp-1 regulation of synaptic function at the neuromuscular junction."xsd:string |
| http://purl.uniprot.org/citations/20501656 | http://purl.uniprot.org/core/volume | "285"xsd:string |
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