| http://purl.uniprot.org/citations/20506166 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20506166 | http://www.w3.org/2000/01/rdf-schema#comment | "In this article, we selectively extracted the nuclear matrix and intermediate filament system of human neuroblastoma SK-N-SH cells pre- and post-treated with retinoic acid (RA). The distribution of nucleophosmin (NPM) in the nuclear matrix and its colocalization with several products of related genes were investigated. Results from two-dimensional gel electrophoresis and MALDI-TOF showed that NPM was a component of the nuclear matrix and its expression in SK-N-SH cells post-treated with RA was down-regulated. Immunofluorescent microscopy observations further showed that NPM was localized in the nuclear matrix of SK-N-SH cells, and its expression level and distribution were altered after treatment with RA. The colocalization of NPM with c-myc, c-fos, p53, and Rb in SK-N-SH cells was observed under a laser scanning confocal microscope, but the colocalization region was changed by RA. Our results prove that NPM is a nuclear matrix protein, which is localized in nuclear matrix fibers. The colocalization of NPM with its related genes and oncogenes affect the differentiation of SK-N-SH cells. The expression of NPM and its distribution in the process of cell differentiation deserve more intensive investigation."xsd:string |
| http://purl.uniprot.org/citations/20506166 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcb.22663"xsd:string |
| http://purl.uniprot.org/citations/20506166 | http://purl.uniprot.org/core/author | "Liang Y."xsd:string |
| http://purl.uniprot.org/citations/20506166 | http://purl.uniprot.org/core/author | "Wang S.Y."xsd:string |
| http://purl.uniprot.org/citations/20506166 | http://purl.uniprot.org/core/author | "Wu F.Y."xsd:string |
| http://purl.uniprot.org/citations/20506166 | http://purl.uniprot.org/core/author | "Zhang X.Y."xsd:string |
| http://purl.uniprot.org/citations/20506166 | http://purl.uniprot.org/core/author | "Li Q.F."xsd:string |
| http://purl.uniprot.org/citations/20506166 | http://purl.uniprot.org/core/author | "Liu Q.R."xsd:string |
| http://purl.uniprot.org/citations/20506166 | http://purl.uniprot.org/core/author | "Shi S.L."xsd:string |
| http://purl.uniprot.org/citations/20506166 | http://purl.uniprot.org/core/author | "Jing G.J."xsd:string |
| http://purl.uniprot.org/citations/20506166 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20506166 | http://purl.uniprot.org/core/name | "J Cell Biochem"xsd:string |
| http://purl.uniprot.org/citations/20506166 | http://purl.uniprot.org/core/pages | "67-74"xsd:string |
| http://purl.uniprot.org/citations/20506166 | http://purl.uniprot.org/core/title | "Localization of nucleophosmin in nuclear matrix and changes in its expression during the differentiation of human neuroblastoma induced by retinoic acid."xsd:string |
| http://purl.uniprot.org/citations/20506166 | http://purl.uniprot.org/core/volume | "111"xsd:string |
| http://purl.uniprot.org/citations/20506166 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20506166 |
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