| http://purl.uniprot.org/citations/20510673 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20510673 | http://www.w3.org/2000/01/rdf-schema#comment | "The epidermal growth factor receptor (EGFR) is a key driver in the process of squamous cell carcinoma (SCC) cell mitogenesis. Phospholipase C-gamma1 (PLC-gamma1) is a downstream target of EGFR signaling, but the role and necessity of PLC-gamma1 in EGFR-induced cell mitogenesis remain unclear. In the present study, we report an elevated expression of PLC-gamma1 in human SCC biopsies relative to adjacent normal epidermis, and in human SCC cell lines compared to normal human keratinocytes. EGFR-induced SCC cell mitogenesis was blocked by small interfering RNA knockdown of PLC-gamma1. However, inhibition of the catalytic activity of phospholipase C had no effect on EGFR-induced SCC cell mitogenesis. In response to the EGFR ligand epidermal growth factor (EGF), PLC-gamma1 was translocated not only to the plasma membrane but also to the nucleus. These data suggest that PLC-gamma1 is required for EGFR-induced SCC cell mitogenesis and the mitogenic function of PLC-gamma1 is independent of its lipase activity."xsd:string |
| http://purl.uniprot.org/citations/20510673 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2010.05.103"xsd:string |
| http://purl.uniprot.org/citations/20510673 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/20510673 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/20510673 | http://purl.uniprot.org/core/author | "Xie Z."xsd:string |
| http://purl.uniprot.org/citations/20510673 | http://purl.uniprot.org/core/author | "Pennypacker S.D."xsd:string |
| http://purl.uniprot.org/citations/20510673 | http://purl.uniprot.org/core/author | "Liu F.Y."xsd:string |
| http://purl.uniprot.org/citations/20510673 | http://purl.uniprot.org/core/author | "Liao E.Y."xsd:string |
| http://purl.uniprot.org/citations/20510673 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20510673 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/20510673 | http://purl.uniprot.org/core/pages | "296-300"xsd:string |
| http://purl.uniprot.org/citations/20510673 | http://purl.uniprot.org/core/title | "Phospholipase C-gamma1 is required for the epidermal growth factor receptor-induced squamous cell carcinoma cell mitogenesis."xsd:string |
| http://purl.uniprot.org/citations/20510673 | http://purl.uniprot.org/core/volume | "397"xsd:string |
| http://purl.uniprot.org/citations/20510673 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20510673 |
| http://purl.uniprot.org/citations/20510673 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20510673 |
| http://purl.uniprot.org/uniprot/P19174#attribution-B2AAB10BC8A1902D7A289652B36588A7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20510673 |
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