| http://purl.uniprot.org/citations/20510926 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20510926 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20510926 | http://www.w3.org/2000/01/rdf-schema#comment | "Inner ear hair cells detect sound through deflection of mechanosensory stereocilia. Each stereocilium is supported by a paracrystalline array of parallel actin filaments that are packed more densely at the base, forming a rootlet extending into the cell body. The function of rootlets and the molecules responsible for their formation are unknown. We found that TRIOBP, a cytoskeleton-associated protein mutated in human hereditary deafness DFNB28, is localized to rootlets. In vitro, purified TRIOBP isoform 4 protein organizes actin filaments into uniquely dense bundles reminiscent of rootlets but distinct from bundles formed by espin, an actin crosslinker in stereocilia. We generated mutant Triobp mice (Triobp(Deltaex8/Deltaex8)) that are profoundly deaf. Stereocilia of Triobp(Deltaex8/Deltaex8) mice develop normally but fail to form rootlets and are easier to deflect and damage. Thus, F-actin bundling by TRIOBP provides durability and rigidity for normal mechanosensitivity of stereocilia and may contribute to resilient cytoskeletal structures elsewhere."xsd:string |
| http://purl.uniprot.org/citations/20510926 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2010.03.049"xsd:string |
| http://purl.uniprot.org/citations/20510926 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2010.03.049"xsd:string |
| http://purl.uniprot.org/citations/20510926 | http://purl.uniprot.org/core/author | "Hammer J.A. III"xsd:string |
| http://purl.uniprot.org/citations/20510926 | http://purl.uniprot.org/core/author | "Hammer J.A. III"xsd:string |
| http://purl.uniprot.org/citations/20510926 | http://purl.uniprot.org/core/author | "Bird J.E."xsd:string |
| http://purl.uniprot.org/citations/20510926 | http://purl.uniprot.org/core/author | "Bird J.E."xsd:string |
| http://purl.uniprot.org/citations/20510926 | http://purl.uniprot.org/core/author | "Ahmed Z.M."xsd:string |
| http://purl.uniprot.org/citations/20510926 | http://purl.uniprot.org/core/author | "Ahmed Z.M."xsd:string |
| http://purl.uniprot.org/citations/20510926 | http://purl.uniprot.org/core/author | "Riazuddin S."xsd:string |
| http://purl.uniprot.org/citations/20510926 | http://purl.uniprot.org/core/author | "Riazuddin S."xsd:string |
| http://purl.uniprot.org/citations/20510926 | http://purl.uniprot.org/core/author | "Sakamoto T."xsd:string |
| http://purl.uniprot.org/citations/20510926 | http://purl.uniprot.org/core/author | "Sakamoto T."xsd:string |
| http://purl.uniprot.org/citations/20510926 | http://purl.uniprot.org/core/author | "Goodyear R.J."xsd:string |
| http://purl.uniprot.org/citations/20510926 | http://purl.uniprot.org/core/author | "Goodyear R.J."xsd:string |
| http://purl.uniprot.org/citations/20510926 | http://purl.uniprot.org/core/author | "Richardson G.P."xsd:string |
| http://purl.uniprot.org/citations/20510926 | http://purl.uniprot.org/core/author | "Richardson G.P."xsd:string |
| http://purl.uniprot.org/citations/20510926 | http://purl.uniprot.org/core/author | "Belyantseva I.A."xsd:string |
| http://purl.uniprot.org/citations/20510926 | http://purl.uniprot.org/core/author | "Belyantseva I.A."xsd:string |
| http://purl.uniprot.org/citations/20510926 | http://purl.uniprot.org/core/author | "Friedman T.B."xsd:string |
| http://purl.uniprot.org/citations/20510926 | http://purl.uniprot.org/core/author | "Friedman T.B."xsd:string |
| http://purl.uniprot.org/citations/20510926 | http://purl.uniprot.org/core/author | "Riazuddin S.'"xsd:string |
| http://purl.uniprot.org/citations/20510926 | http://purl.uniprot.org/core/author | "Riazuddin S.'"xsd:string |