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| http://purl.uniprot.org/citations/20516060 | http://www.w3.org/2000/01/rdf-schema#comment | "Pancreatic beta-cells are vulnerable to multiple stresses, leading to dysfunction and apoptotic death. Deterioration in beta-cells function and mass is associated with type 2 diabetes. Comparative two-dimensional gel electrophoresis from pancreatic MIN6 cells that were maintained at varying glucose concentrations was carried out. An induced expression of a protein spot, detected in MIN6 cells experiencing high glucose concentration, was identified by mass spectrometry as the oxidized form of DJ-1. DJ-1 (park7) is a multifunctional protein implicated in familial Parkinsonism and neuroprotection in response to oxidative damage. The DJ-1 protein and its oxidized form were also induced following exposure to oxidative and endoplasmic reticulum stress in MIN6 and betaTC-6 cells and also in mouse pancreatic islets. Suppression of DJ-1 levels by small interfering RNA led to an accelerated cell death, whereas an increase in DJ-1 levels by adenovirus-based infection attenuated cell death induced by H(2)O(2) and thapsigargin in beta-cell lines and mouse pancreatic islets. Furthermore, DJ-1 improved regulated insulin secretion under basal as well as oxidative and endoplasmic reticulum stress conditions in a dose-dependent manner. We identified TFII-I (Gtf2i) as DJ-1 partner in the cytosol, whereas the binding of TFII-I to DJ-1 prevented TFII-I translocation to the nucleus. The outcome was attenuation of the stress response. Our results suggest that DJ-1 together with TFII-I operate in concert to cope with various insults and to sustain pancreatic beta-cell function."xsd:string |
| http://purl.uniprot.org/citations/20516060 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.109751"xsd:string |
| http://purl.uniprot.org/citations/20516060 | http://purl.uniprot.org/core/author | "Linial M."xsd:string |
| http://purl.uniprot.org/citations/20516060 | http://purl.uniprot.org/core/author | "Inberg A."xsd:string |
| http://purl.uniprot.org/citations/20516060 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20516060 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/20516060 | http://purl.uniprot.org/core/pages | "25686-25698"xsd:string |
| http://purl.uniprot.org/citations/20516060 | http://purl.uniprot.org/core/title | "Protection of pancreatic beta-cells from various stress conditions is mediated by DJ-1."xsd:string |
| http://purl.uniprot.org/citations/20516060 | http://purl.uniprot.org/core/volume | "285"xsd:string |
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