| http://purl.uniprot.org/citations/20516195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20516195 | http://www.w3.org/2000/01/rdf-schema#comment | "Deciphering molecular events required for full transformation of normal cells into cancer cells remains a challenge. In T-cell acute lymphoblastic leukemia (T-ALL), the genes encoding the TAL1/SCL and LMO1/2 transcription factors are recurring targets of chromosomal translocations, whereas NOTCH1 is activated in >50% of samples. Here we show that the SCL and LMO1 oncogenes collaborate to expand primitive thymocyte progenitors and inhibit later stages of differentiation. Together with pre-T-cell antigen receptor (pre-TCR) signaling, these oncogenes provide a favorable context for the acquisition of activating Notch1 mutations and the emergence of self-renewing leukemia-initiating cells in T-ALL. All tumor cells harness identical and specific Notch1 mutations and Tcrbeta clonal signature, indicative of clonal dominance and concurring with the observation that Notch1 gain of function confers a selective advantage to SCL-LMO1 transgenic thymocytes. Accordingly, a hyperactive Notch1 allele accelerates leukemia onset induced by SCL-LMO1 and bypasses the requirement for pre-TCR signaling. Finally, the time to leukemia induced by the three transgenes corresponds to the time required for clonal expansion from a single leukemic stem cell, suggesting that SCL, LMO1, and Notch1 gain of function, together with an active pre-TCR, might represent the minimum set of complementing events for the transformation of susceptible thymocytes."xsd:string |
| http://purl.uniprot.org/citations/20516195 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.1897910"xsd:string |
| http://purl.uniprot.org/citations/20516195 | http://purl.uniprot.org/core/author | "Hebert J."xsd:string |
| http://purl.uniprot.org/citations/20516195 | http://purl.uniprot.org/core/author | "Hoang T."xsd:string |
| http://purl.uniprot.org/citations/20516195 | http://purl.uniprot.org/core/author | "Perreault C."xsd:string |
| http://purl.uniprot.org/citations/20516195 | http://purl.uniprot.org/core/author | "Aplan P.D."xsd:string |
| http://purl.uniprot.org/citations/20516195 | http://purl.uniprot.org/core/author | "Tremblay M."xsd:string |
| http://purl.uniprot.org/citations/20516195 | http://purl.uniprot.org/core/author | "Tremblay C.S."xsd:string |
| http://purl.uniprot.org/citations/20516195 | http://purl.uniprot.org/core/author | "Herblot S."xsd:string |
| http://purl.uniprot.org/citations/20516195 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20516195 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/20516195 | http://purl.uniprot.org/core/pages | "1093-1105"xsd:string |
| http://purl.uniprot.org/citations/20516195 | http://purl.uniprot.org/core/title | "Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes."xsd:string |
| http://purl.uniprot.org/citations/20516195 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/20516195 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20516195 |
| http://purl.uniprot.org/citations/20516195 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20516195 |
| http://purl.uniprot.org/uniprot/#_A0A1D8M9B3-mappedCitation-20516195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20516195 |
| http://purl.uniprot.org/uniprot/#_A0A140LHX4-mappedCitation-20516195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20516195 |
| http://purl.uniprot.org/uniprot/#_A0A140LIB4-mappedCitation-20516195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20516195 |
| http://purl.uniprot.org/uniprot/#_A0A494B9G5-mappedCitation-20516195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20516195 |
| http://purl.uniprot.org/uniprot/#_A0A494B9U2-mappedCitation-20516195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20516195 |
| http://purl.uniprot.org/uniprot/#_A6H6M1-mappedCitation-20516195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20516195 |
| http://purl.uniprot.org/uniprot/#_A2AD40-mappedCitation-20516195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20516195 |
| http://purl.uniprot.org/uniprot/#_B0LAX5-mappedCitation-20516195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20516195 |