| http://purl.uniprot.org/citations/20516642 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20516642 | http://www.w3.org/2000/01/rdf-schema#comment | "Despite significant advancements in our understanding of cancer development, the molecular mechanisms that underlie the formation of liver cancer remain largely unknown. C/EBPalpha is a transcription factor that regulates liver quiescence. Phosphorylation of C/EBPalpha at serine 193 (S193-ph) is upregulated in older mice and is thought to contribute to age-associated liver dysfunction. Because development of liver tumors is associated with increasing age, we investigated the role of S193-ph in the development of liver cancer using knockin mice expressing a phospho-mimetic aspartic acid residue in place of serine at position 193 (S193D) of C/EBPalpha. The S193D isoform of C/EBPalpha was able to completely inhibit liver proliferation in vivo after partial hepatectomy. However, treatment of these mice with diethylnitrosamine/phenobarbital (DEN/PB), which induces formation of liver cancer, actually resulted in earlier development of liver tumors. DEN/PB treatment was associated with specific degradation of both the S193-ph and S193D isoforms of C/EBPalpha through activation of the ubiquitinproteasome system (UPS). The mechanism of UPS-mediated elimination of C/EBPalpha during carcinogenesis involved elevated levels of gankyrin, a protein that was found to interact with the S193-ph isoform of C/EBPalpha and target it for UPS-mediated degradation. This study identifies a molecular mechanism that supports the development of liver cancer in older mice and potential therapeutic targets for the prevention of liver cancer."xsd:string |
| http://purl.uniprot.org/citations/20516642 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci41933"xsd:string |
| http://purl.uniprot.org/citations/20516642 | http://purl.uniprot.org/core/author | "Jin J."xsd:string |
| http://purl.uniprot.org/citations/20516642 | http://purl.uniprot.org/core/author | "Shi X."xsd:string |
| http://purl.uniprot.org/citations/20516642 | http://purl.uniprot.org/core/author | "Wang G.L."xsd:string |
| http://purl.uniprot.org/citations/20516642 | http://purl.uniprot.org/core/author | "Timchenko N.A."xsd:string |
| http://purl.uniprot.org/citations/20516642 | http://purl.uniprot.org/core/author | "Finegold M."xsd:string |
| http://purl.uniprot.org/citations/20516642 | http://purl.uniprot.org/core/author | "Iakova P."xsd:string |
| http://purl.uniprot.org/citations/20516642 | http://purl.uniprot.org/core/author | "Major A."xsd:string |
| http://purl.uniprot.org/citations/20516642 | http://purl.uniprot.org/core/author | "Haefliger S."xsd:string |
| http://purl.uniprot.org/citations/20516642 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20516642 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/20516642 | http://purl.uniprot.org/core/pages | "2549-2562"xsd:string |
| http://purl.uniprot.org/citations/20516642 | http://purl.uniprot.org/core/title | "Elimination of C/EBPalpha through the ubiquitin-proteasome system promotes the development of liver cancer in mice."xsd:string |
| http://purl.uniprot.org/citations/20516642 | http://purl.uniprot.org/core/volume | "120"xsd:string |
| http://purl.uniprot.org/citations/20516642 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20516642 |
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