| http://purl.uniprot.org/citations/20519123 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20519123 | http://www.w3.org/2000/01/rdf-schema#comment | "Development of osteoporosis severely complicates long-term glucocorticoid (GC) therapy. Using a Cre-transgenic mouse line, we now demonstrate that GCs are unable to repress bone formation in the absence of glucocorticoid receptor (GR) expression in osteoblasts as they become refractory to hormone-induced apoptosis, inhibition of proliferation, and differentiation. In contrast, GC treatment still reduces bone formation in mice carrying a mutation that only disrupts GR dimerization, resulting in bone loss in vivo, enhanced apoptosis, and suppressed differentiation in vitro. The inhibitory GC effects on osteoblasts can be explained by a mechanism involving suppression of cytokines, such as interleukin 11, via interaction of the monomeric GR with AP-1, but not NF-kappaB. Thus, GCs inhibit cytokines independent of GR dimerization and thereby attenuate osteoblast differentiation, which accounts, in part, for bone loss during GC therapy."xsd:string |
| http://purl.uniprot.org/citations/20519123 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2010.05.005"xsd:string |
| http://purl.uniprot.org/citations/20519123 | http://purl.uniprot.org/core/author | "Schmidt-Ullrich R."xsd:string |
| http://purl.uniprot.org/citations/20519123 | http://purl.uniprot.org/core/author | "Seitz S."xsd:string |
| http://purl.uniprot.org/citations/20519123 | http://purl.uniprot.org/core/author | "Rauch A."xsd:string |
| http://purl.uniprot.org/citations/20519123 | http://purl.uniprot.org/core/author | "Illing A."xsd:string |
| http://purl.uniprot.org/citations/20519123 | http://purl.uniprot.org/core/author | "Schinke T."xsd:string |
| http://purl.uniprot.org/citations/20519123 | http://purl.uniprot.org/core/author | "Amling M."xsd:string |
| http://purl.uniprot.org/citations/20519123 | http://purl.uniprot.org/core/author | "Schutz G."xsd:string |
| http://purl.uniprot.org/citations/20519123 | http://purl.uniprot.org/core/author | "Mandic V."xsd:string |
| http://purl.uniprot.org/citations/20519123 | http://purl.uniprot.org/core/author | "Schilling A.F."xsd:string |
| http://purl.uniprot.org/citations/20519123 | http://purl.uniprot.org/core/author | "Reichardt H.M."xsd:string |
| http://purl.uniprot.org/citations/20519123 | http://purl.uniprot.org/core/author | "Tuckermann J.P."xsd:string |
| http://purl.uniprot.org/citations/20519123 | http://purl.uniprot.org/core/author | "David J.P."xsd:string |
| http://purl.uniprot.org/citations/20519123 | http://purl.uniprot.org/core/author | "Spanbroek R."xsd:string |
| http://purl.uniprot.org/citations/20519123 | http://purl.uniprot.org/core/author | "Lerner U.H."xsd:string |
| http://purl.uniprot.org/citations/20519123 | http://purl.uniprot.org/core/author | "Stride B."xsd:string |
| http://purl.uniprot.org/citations/20519123 | http://purl.uniprot.org/core/author | "Zaiss M.M."xsd:string |
| http://purl.uniprot.org/citations/20519123 | http://purl.uniprot.org/core/author | "Kirilov M."xsd:string |
| http://purl.uniprot.org/citations/20519123 | http://purl.uniprot.org/core/author | "Angel P.E."xsd:string |
| http://purl.uniprot.org/citations/20519123 | http://purl.uniprot.org/core/author | "Baschant U."xsd:string |
| http://purl.uniprot.org/citations/20519123 | http://purl.uniprot.org/core/author | "Ostermay S."xsd:string |
| http://purl.uniprot.org/citations/20519123 | http://purl.uniprot.org/core/author | "Takacz A."xsd:string |
| http://purl.uniprot.org/citations/20519123 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |