| http://purl.uniprot.org/citations/20520819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20520819 | http://www.w3.org/2000/01/rdf-schema#comment | "Patients with Alzheimer's disease (AD) exhibit substantial accumulation of amyloid-beta (Abeta) plaques in the brain. Here, we examine whether Abeta vaccination can facilitate the migration of T lymphocytes to specifically target Abeta plaques and consequently enhance their removal. Using a new mouse model of AD, we show that immunization with Abeta, but not with the encephalitogenic proteolipid protein (PLP), results in the accumulation of T cells at Abeta plaques in the brain. Although both Abeta-reactive and PLP-reactive T cells have a similar phenotype of Th1 cells secreting primarily IFN-gamma, the encephalitogenic T cells penetrated the spinal cord and caused experimental autoimmune encephalomyelitis (EAE), whereas Abeta T cells accumulated primarily at Abeta plaques in the brain but not the spinal cord and induced almost complete clearance of Abeta. Furthermore, while a single vaccination with Abeta resulted in upregulation of the phagocytic markers triggering receptors expressed on myeloid cells-2 (TREM2) and signal regulatory protein-beta1 (SIRPbeta1) in the brain, it caused downregulation of the proinflammatory cytokines TNF-alpha and IL-6. We thus suggest that Abeta deposits in the hippocampus area prioritize the targeting of Abeta-reactive but not PLP-reactive T cells upon vaccination. The stimulation of Abeta-reactive T cells at sites of Abeta plaques resulted in IFN-gamma-induced chemotaxis of leukocytes and therapeutic clearance of Abeta."xsd:string |
| http://purl.uniprot.org/citations/20520819 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0010830"xsd:string |
| http://purl.uniprot.org/citations/20520819 | http://purl.uniprot.org/core/author | "Baron R."xsd:string |
| http://purl.uniprot.org/citations/20520819 | http://purl.uniprot.org/core/author | "Monsonego A."xsd:string |
| http://purl.uniprot.org/citations/20520819 | http://purl.uniprot.org/core/author | "Fisher Y."xsd:string |
| http://purl.uniprot.org/citations/20520819 | http://purl.uniprot.org/core/author | "Nemirovsky A."xsd:string |
| http://purl.uniprot.org/citations/20520819 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20520819 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/20520819 | http://purl.uniprot.org/core/pages | "e10830"xsd:string |
| http://purl.uniprot.org/citations/20520819 | http://purl.uniprot.org/core/title | "T cells specifically targeted to amyloid plaques enhance plaque clearance in a mouse model of Alzheimer's disease."xsd:string |
| http://purl.uniprot.org/citations/20520819 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/20520819 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20520819 |
| http://purl.uniprot.org/citations/20520819 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20520819 |
| http://purl.uniprot.org/uniprot/#_E0CXT9-mappedCitation-20520819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20520819 |
| http://purl.uniprot.org/uniprot/#_E0CYH3-mappedCitation-20520819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20520819 |
| http://purl.uniprot.org/uniprot/#_E0CYJ9-mappedCitation-20520819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20520819 |
| http://purl.uniprot.org/uniprot/#_E0CX28-mappedCitation-20520819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20520819 |
| http://purl.uniprot.org/uniprot/#_E0CXK1-mappedCitation-20520819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20520819 |
| http://purl.uniprot.org/uniprot/#_Q9QZF3-mappedCitation-20520819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20520819 |
| http://purl.uniprot.org/uniprot/#_Q8K0L9-mappedCitation-20520819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20520819 |
| http://purl.uniprot.org/uniprot/#_Q8CAI3-mappedCitation-20520819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20520819 |
| http://purl.uniprot.org/uniprot/E0CYH3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20520819 |
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| http://purl.uniprot.org/uniprot/Q8K0L9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20520819 |