| http://purl.uniprot.org/citations/20526344 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20526344 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20526344 | http://www.w3.org/2000/01/rdf-schema#comment | "Anaphylaxis is a life-threatening immediate hypersensitivity reaction triggered by antigen capture by immunoglobulin E (IgE) bound to the high-affinity IgE receptor (FcvarepsilonRI) on mast cells. However, the regulatory mechanism of mast cell activation is not completely understood. Here we identify an immunoglobulin-like receptor, Allergin-1, that contains an immunoreceptor tyrosine-based inhibitory motif (ITIM)-like domain, and show it was preferentially expressed on mast cells. Mouse Allergin-1 recruited the tyrosine phosphatases SHP-1 and SHP-2 and the inositol phosphatase SHIP. Coligation of Allergin-1 and FcvarepsilonRI suppressed IgE-mediated degranulation of bone marrow-derived cultured mast cells. Moreover, mice deficient in Allergin-1 developed enhanced passive systemic and cutaneous anaphylaxis. Thus, Allergin-1 suppresses IgE-mediated, mast cell-dependent anaphylaxis in mice."xsd:string |
| http://purl.uniprot.org/citations/20526344 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.1886"xsd:string |
| http://purl.uniprot.org/citations/20526344 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.1886"xsd:string |
| http://purl.uniprot.org/citations/20526344 | http://purl.uniprot.org/core/author | "Shibuya K."xsd:string |
| http://purl.uniprot.org/citations/20526344 | http://purl.uniprot.org/core/author | "Shibuya K."xsd:string |
| http://purl.uniprot.org/citations/20526344 | http://purl.uniprot.org/core/author | "Sugiyama T."xsd:string |
| http://purl.uniprot.org/citations/20526344 | http://purl.uniprot.org/core/author | "Sugiyama T."xsd:string |
| http://purl.uniprot.org/citations/20526344 | http://purl.uniprot.org/core/author | "Hitomi K."xsd:string |
| http://purl.uniprot.org/citations/20526344 | http://purl.uniprot.org/core/author | "Hitomi K."xsd:string |
| http://purl.uniprot.org/citations/20526344 | http://purl.uniprot.org/core/author | "Tada H."xsd:string |
| http://purl.uniprot.org/citations/20526344 | http://purl.uniprot.org/core/author | "Tada H."xsd:string |
| http://purl.uniprot.org/citations/20526344 | http://purl.uniprot.org/core/author | "Shibuya A."xsd:string |
| http://purl.uniprot.org/citations/20526344 | http://purl.uniprot.org/core/author | "Shibuya A."xsd:string |
| http://purl.uniprot.org/citations/20526344 | http://purl.uniprot.org/core/author | "Tahara-Hanaoka S."xsd:string |
| http://purl.uniprot.org/citations/20526344 | http://purl.uniprot.org/core/author | "Tahara-Hanaoka S."xsd:string |
| http://purl.uniprot.org/citations/20526344 | http://purl.uniprot.org/core/author | "Shibayama S."xsd:string |
| http://purl.uniprot.org/citations/20526344 | http://purl.uniprot.org/core/author | "Shibayama S."xsd:string |
| http://purl.uniprot.org/citations/20526344 | http://purl.uniprot.org/core/author | "Fujiki A."xsd:string |
| http://purl.uniprot.org/citations/20526344 | http://purl.uniprot.org/core/author | "Fujiki A."xsd:string |
| http://purl.uniprot.org/citations/20526344 | http://purl.uniprot.org/core/author | "Someya S."xsd:string |
| http://purl.uniprot.org/citations/20526344 | http://purl.uniprot.org/core/author | "Someya S."xsd:string |
| http://purl.uniprot.org/citations/20526344 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20526344 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |