| http://purl.uniprot.org/citations/20529116 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20529116 | http://www.w3.org/2000/01/rdf-schema#comment | "The serine protease inhibitor protease-nexin-1 (PN-1) has been shown to modulate N-methyl-d-aspartate receptor (NMDAR)-mediated synaptic currents and NMDAR-dependent long-term potentiation of synaptic transmission. Here, we analysed the role of PN-1 in the acquisition and extinction of classical auditory fear conditioning, two distinct forms of learning that both depend on NMDAR activity in the amygdala. Immunostaining revealed that PN-1 is expressed throughout the amygdala, primarily in gamma-aminobutyric acid containing neurons of the central amygdala and intercalated cell masses (ITCs) and in glia. Fear extinction was severely impaired in mice lacking PN-1 (PN-1 KO). Consistent with a role for the basal nucleus of the amygdala in fear extinction, we found that, compared with wild-type (WT) littermate controls, PN-1 KO mice exhibited decreased numbers of Fos-positive neurons in the basal nucleus after extinction. Moreover, immunoblot analysis of laser-microdissected amygdala sub-nuclei revealed specific extinction-induced increases in the level of phosphorylated alpha-calcium/calmodulin protein kinase II in the medial ITCs and in the lateral subdivision of the central amygdala in WT mice. These responses were altered in PN-1 KO mice. Together, these data indicate that lack of extinction in PN-1 KO mice is associated with distinct changes in neuronal activity across the circuitry of the basal and central nuclei and the ITCs, supporting a differential impact on fear extinction of these amygdala substructures. They also suggest a new role for serine protease inhibitors such as PN-1 in modulating fear conditioning and extinction."xsd:string |
| http://purl.uniprot.org/citations/20529116 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1460-9568.2010.07221.x"xsd:string |
| http://purl.uniprot.org/citations/20529116 | http://purl.uniprot.org/core/author | "Moreno E."xsd:string |
| http://purl.uniprot.org/citations/20529116 | http://purl.uniprot.org/core/author | "Muller C."xsd:string |
| http://purl.uniprot.org/citations/20529116 | http://purl.uniprot.org/core/author | "Meins M."xsd:string |
| http://purl.uniprot.org/citations/20529116 | http://purl.uniprot.org/core/author | "Monard D."xsd:string |
| http://purl.uniprot.org/citations/20529116 | http://purl.uniprot.org/core/author | "Luthi A."xsd:string |
| http://purl.uniprot.org/citations/20529116 | http://purl.uniprot.org/core/author | "Ciocchi S."xsd:string |
| http://purl.uniprot.org/citations/20529116 | http://purl.uniprot.org/core/author | "Herry C."xsd:string |
| http://purl.uniprot.org/citations/20529116 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20529116 | http://purl.uniprot.org/core/name | "Eur J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/20529116 | http://purl.uniprot.org/core/pages | "2033-2042"xsd:string |
| http://purl.uniprot.org/citations/20529116 | http://purl.uniprot.org/core/title | "Impaired fear extinction in mice lacking protease nexin-1."xsd:string |
| http://purl.uniprot.org/citations/20529116 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/20529116 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20529116 |
| http://purl.uniprot.org/citations/20529116 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20529116 |
| http://purl.uniprot.org/uniprot/#_A0A087WQ70-mappedCitation-20529116 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20529116 |
| http://purl.uniprot.org/uniprot/#_A0A087WQM1-mappedCitation-20529116 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20529116 |
| http://purl.uniprot.org/uniprot/#_Q07235-mappedCitation-20529116 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20529116 |
| http://purl.uniprot.org/uniprot/#_Q3TWH7-mappedCitation-20529116 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20529116 |
| http://purl.uniprot.org/uniprot/#_Q4FJU1-mappedCitation-20529116 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20529116 |
| http://purl.uniprot.org/uniprot/#_Q543R5-mappedCitation-20529116 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20529116 |
| http://purl.uniprot.org/uniprot/Q07235 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20529116 |
| http://purl.uniprot.org/uniprot/Q543R5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20529116 |