| http://purl.uniprot.org/citations/20529123 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20529123 | http://www.w3.org/2000/01/rdf-schema#comment | "During neuronal maturation, the neuron-specific K-Cl co-transporter KCC2 lowers the intracellular chloride and thereby renders GABAergic transmission hyperpolarizing. Independently of its role as a co-transporter, KCC2 plays a crucial role in the maturation of dendritic spines, most probably via an interaction with the cytoskeleton-associated protein 4.1N. In this study, we show that neural-specific overexpression of KCC2 impairs the development of the neural tube- and neural crest-related structures in mouse embryos. At early stages (E9.5-11.5), the transgenic embryos had a thinner neural tube and abnormal body curvature. They displayed a reduced neuronal differentiation and altered neural crest cell pattern. At later stages (E11.5-15.5), the transgenic embryos had smaller brain structures and a distinctive cleft palate. Similar results were obtained using overexpression of a transport-inactive N-terminal-deleted variant of KCC2, implying that the effects were not dependent on KCC2's role as a K-Cl co-transporter. Interestingly, the neural tube of transgenic embryos had an aberrant cytoplasmic distribution of 4.1N and actin. This was corroborated in a neural stem cell line with ectopic expression of KCC2. Embryo phenotype and cell morphology were unaffected by a mutated variant of KCC2 which is unable to bind 4.1N. These results point to a role of KCC2 in neuronal differentiation and migration during early development mediated by its direct structural interactions with the neuronal cytoskeleton."xsd:string |
| http://purl.uniprot.org/citations/20529123 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1460-9568.2010.07258.x"xsd:string |
| http://purl.uniprot.org/citations/20529123 | http://purl.uniprot.org/core/author | "Herlenius E."xsd:string |
| http://purl.uniprot.org/citations/20529123 | http://purl.uniprot.org/core/author | "Blaesse P."xsd:string |
| http://purl.uniprot.org/citations/20529123 | http://purl.uniprot.org/core/author | "Kaila K."xsd:string |
| http://purl.uniprot.org/citations/20529123 | http://purl.uniprot.org/core/author | "Ringstedt T."xsd:string |
| http://purl.uniprot.org/citations/20529123 | http://purl.uniprot.org/core/author | "Horn Z."xsd:string |
| http://purl.uniprot.org/citations/20529123 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20529123 | http://purl.uniprot.org/core/name | "Eur J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/20529123 | http://purl.uniprot.org/core/pages | "2142-2155"xsd:string |
| http://purl.uniprot.org/citations/20529123 | http://purl.uniprot.org/core/title | "Premature expression of KCC2 in embryonic mice perturbs neural development by an ion transport-independent mechanism."xsd:string |
| http://purl.uniprot.org/citations/20529123 | http://purl.uniprot.org/core/volume | "31"xsd:string |
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