| http://purl.uniprot.org/citations/20531249 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20531249 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20531249 | http://www.w3.org/2000/01/rdf-schema#comment | "Human preterm infants with necrotizing enterocolitis (NEC) have increased circulating and luminal levels of platelet-activating factor (PAF) and decreased serum PAF-acetylhydrolase (PAF-AH), the enzyme that inactivates PAF. Formula supplemented with recombinant PAF-AH decreases NEC in a neonatal rat model. We hypothesized that endogenous PAF-AH contributes to neonatal intestinal homeostasis and therefore developed PAF-AH mice using standard approaches to study the role of this enzyme in the neonatal NEC model. After exposure to a well-established NEC model, intestinal tissues were evaluated for histology, proinflammatory cytokine mRNA synthesis, and death using standard techniques. We found that mortality rates were significantly lower in PAF-AH pups compared with wild-type controls before 24 h of life but surviving PAF-AH animals were more susceptible to NEC development compared with wild-type controls. Increased NEC incidence was associated with prominent inflammation characterized by elevated intestinal mRNA expression of sPLA2, inducible NOS, and CXCL1. In conclusion, the data support a protective role for endogenous PAF-AH in the development of NEC, and because preterm neonates have endogenous PAF-AH deficiency, this may place them at increased risk for disease."xsd:string |
| http://purl.uniprot.org/citations/20531249 | http://purl.org/dc/terms/identifier | "doi:10.1203/pdr.0b013e3181eb2efe"xsd:string |
| http://purl.uniprot.org/citations/20531249 | http://purl.org/dc/terms/identifier | "doi:10.1203/pdr.0b013e3181eb2efe"xsd:string |
| http://purl.uniprot.org/citations/20531249 | http://purl.uniprot.org/core/author | "Lu J."xsd:string |
| http://purl.uniprot.org/citations/20531249 | http://purl.uniprot.org/core/author | "Lu J."xsd:string |
| http://purl.uniprot.org/citations/20531249 | http://purl.uniprot.org/core/author | "Caplan M."xsd:string |
| http://purl.uniprot.org/citations/20531249 | http://purl.uniprot.org/core/author | "Caplan M."xsd:string |
| http://purl.uniprot.org/citations/20531249 | http://purl.uniprot.org/core/author | "Franklin A."xsd:string |
| http://purl.uniprot.org/citations/20531249 | http://purl.uniprot.org/core/author | "Franklin A."xsd:string |
| http://purl.uniprot.org/citations/20531249 | http://purl.uniprot.org/core/author | "Pierce M."xsd:string |
| http://purl.uniprot.org/citations/20531249 | http://purl.uniprot.org/core/author | "Pierce M."xsd:string |
| http://purl.uniprot.org/citations/20531249 | http://purl.uniprot.org/core/author | "Stafforini D.M."xsd:string |
| http://purl.uniprot.org/citations/20531249 | http://purl.uniprot.org/core/author | "Stafforini D.M."xsd:string |
| http://purl.uniprot.org/citations/20531249 | http://purl.uniprot.org/core/author | "Jilling T."xsd:string |
| http://purl.uniprot.org/citations/20531249 | http://purl.uniprot.org/core/author | "Jilling T."xsd:string |
| http://purl.uniprot.org/citations/20531249 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20531249 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20531249 | http://purl.uniprot.org/core/name | "Pediatr. Res."xsd:string |
| http://purl.uniprot.org/citations/20531249 | http://purl.uniprot.org/core/name | "Pediatr. Res."xsd:string |
| http://purl.uniprot.org/citations/20531249 | http://purl.uniprot.org/core/pages | "225-230"xsd:string |
| http://purl.uniprot.org/citations/20531249 | http://purl.uniprot.org/core/pages | "225-230"xsd:string |
| http://purl.uniprot.org/citations/20531249 | http://purl.uniprot.org/core/title | "Dual roles of endogenous platelet-activating factor acetylhydrolase in a murine model of necrotizing enterocolitis."xsd:string |
| http://purl.uniprot.org/citations/20531249 | http://purl.uniprot.org/core/title | "Dual roles of endogenous platelet-activating factor acetylhydrolase in a murine model of necrotizing enterocolitis."xsd:string |