| http://purl.uniprot.org/citations/20531346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20531346 | http://www.w3.org/2000/01/rdf-schema#comment | "Genetic variations in dysbindin-1 (dystrobrevin-binding protein-1) are one of the most commonly reported variations associated with schizophrenia. As schizophrenia could be regarded as a neurodevelopmental disorder resulting from abnormalities of synaptic connectivity, we attempted to clarify the function of dysbindin-1 in neuronal development. We examined the developmental change of dysbindin-1 in rat brain by western blotting and found that a 50 kDa isoform is highly expressed during the embryonic stage, whereas a 40 kDa one is detected at postnatal day 11 and increased thereafter. Immunofluorescent analyses revealed that dysbindin-1 is enriched at the spine-like structure of primary cultured rat hippocampal neurons. We identified WAVE2, but not N-WASP, as a binding partner for dysbindin-1. We also found that Abi-1, a binding molecule for WAVE2 involved in spine morphogenesis, interacts with dysbindin-1. Although dysbindin-1, WAVE2 and Abi-1 form a ternary complex, dysbindin-1 promoted the binding of WAVE2 to Abi-1. RNA interference-mediated knockdown of dysbindin-1 led to the generation of abnormally elongated immature dendritic protrusions. The present results indicate possible functions of dysbindin-1 at the postsynapse in the regulation of dendritic spine morphogenesis through the interaction with WAVE2 and Abi-1."xsd:string |
| http://purl.uniprot.org/citations/20531346 | http://purl.org/dc/terms/identifier | "doi:10.1038/mp.2010.69"xsd:string |
| http://purl.uniprot.org/citations/20531346 | http://purl.uniprot.org/core/author | "Ito H."xsd:string |
| http://purl.uniprot.org/citations/20531346 | http://purl.uniprot.org/core/author | "Morishita R."xsd:string |
| http://purl.uniprot.org/citations/20531346 | http://purl.uniprot.org/core/author | "Okamoto K."xsd:string |
| http://purl.uniprot.org/citations/20531346 | http://purl.uniprot.org/core/author | "Shinoda T."xsd:string |
| http://purl.uniprot.org/citations/20531346 | http://purl.uniprot.org/core/author | "Nagata K."xsd:string |
| http://purl.uniprot.org/citations/20531346 | http://purl.uniprot.org/core/author | "Sudo K."xsd:string |
| http://purl.uniprot.org/citations/20531346 | http://purl.uniprot.org/core/author | "Iwamoto I."xsd:string |
| http://purl.uniprot.org/citations/20531346 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20531346 | http://purl.uniprot.org/core/name | "Mol Psychiatry"xsd:string |
| http://purl.uniprot.org/citations/20531346 | http://purl.uniprot.org/core/pages | "976-986"xsd:string |
| http://purl.uniprot.org/citations/20531346 | http://purl.uniprot.org/core/title | "Dysbindin-1, WAVE2 and Abi-1 form a complex that regulates dendritic spine formation."xsd:string |
| http://purl.uniprot.org/citations/20531346 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/20531346 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20531346 |
| http://purl.uniprot.org/citations/20531346 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20531346 |
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