| http://purl.uniprot.org/citations/20533298 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20533298 | http://www.w3.org/2000/01/rdf-schema#comment | "Accumulating evidence suggests that mesenchymal stem cells (MSCs) may decrease destructive inflammation and reduce tissue loss. Tumor necrosis factor-α (TNF-α) plays a central role in induction of proinflammatory signaling and paradoxically activates intracellular anti-inflammatory survival pathways. In this study, we investigated whether TNF-α could induce a chemotactic effect on human MSCs and stimulate their production of anti-inflammatory factors in vitro, as well as determined mechanisms that mediated this effect. Migration assays demonstrated that TNF-α had a chemotactic effect on MSCs. TNF-α increased both hepatocyte growth factor (HGF) mRNA expression in MSCs and HGF secretion in conditioned medium. These effects were dependent on the p38 MAPK and PI3K/Akt, but not JNK and ERK signaling pathways. Furthermore, these effects were inhibited by a specific neutralizing antibody to TNF receptor II, but not TNF receptor I. We conclude that TNF-α can enhance human MSCs migration and stimulate their production of HGF. These effects are mediated via a specific TNF receptor and signaling pathways."xsd:string |
| http://purl.uniprot.org/citations/20533298 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcb.22729"xsd:string |
| http://purl.uniprot.org/citations/20533298 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/20533298 | http://purl.uniprot.org/core/author | "Zhou L."xsd:string |
| http://purl.uniprot.org/citations/20533298 | http://purl.uniprot.org/core/author | "Zhang A."xsd:string |
| http://purl.uniprot.org/citations/20533298 | http://purl.uniprot.org/core/author | "Ye Z."xsd:string |
| http://purl.uniprot.org/citations/20533298 | http://purl.uniprot.org/core/author | "Zheng S."xsd:string |
| http://purl.uniprot.org/citations/20533298 | http://purl.uniprot.org/core/author | "Xie H."xsd:string |
| http://purl.uniprot.org/citations/20533298 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20533298 | http://purl.uniprot.org/core/name | "J Cell Biochem"xsd:string |
| http://purl.uniprot.org/citations/20533298 | http://purl.uniprot.org/core/pages | "469-475"xsd:string |
| http://purl.uniprot.org/citations/20533298 | http://purl.uniprot.org/core/title | "Mechanism of TNF-alpha-induced migration and hepatocyte growth factor production in human mesenchymal stem cells."xsd:string |
| http://purl.uniprot.org/citations/20533298 | http://purl.uniprot.org/core/volume | "111"xsd:string |
| http://purl.uniprot.org/citations/20533298 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20533298 |
| http://purl.uniprot.org/citations/20533298 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20533298 |
| http://purl.uniprot.org/uniprot/#_C9WSJ3-mappedCitation-20533298 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20533298 |
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