| http://purl.uniprot.org/citations/20533548 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20533548 | http://www.w3.org/2000/01/rdf-schema#comment | "Transforming growth factor-β1 (TGF-β1) induces stromal fibroblast-to-myofibroblast transdifferentiation in the tumor-stroma interactive microenvironment via modulation of multiple phenotypic and functional genes, which plays a critical role in tumor progression. Up to now, the involvement of micro-RNAs (miRNAs) and their roles in TGF-β1-induced myofibroblast differentiation in tumor-stroma interaction are unclear. Using quantitative real-time RT-PCR, we demonstrated that the expression of micro-RNA-21 (miR-21) was upregulated in activated fibroblasts after treatment with TGF-β1 or conditioned medium from cancer cells. To determine the potential roles of miR-21 in TGF-β1-mediated gene regulation during myofibroblast conversion, we showed that miR-21 expression was downregulated by miR-21 inhibitor and upregulated by miR-21 mimic. Interestingly, downregulation of miR-21 with the inhibitor effectively inhibited TGF-β1-induced myofibroblast differentiation while upregulation of miR-21 with a mimic significantly promoted myofibroblast differentiation. We further demonstrated that MiR-21 directly targeted and downregulated programmed cell death 4 (PDCD4) gene, which in turn acted as a negative regulator of several phenotypic and functional genes of myofibroblasts. Taken together, these results suggested that miR-21 participated in TGF-β1-induced myofibroblast transdifferentiation in cancer stroma by targeting PDCD4."xsd:string |
| http://purl.uniprot.org/citations/20533548 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.25506"xsd:string |
| http://purl.uniprot.org/citations/20533548 | http://purl.uniprot.org/core/author | "Cao S."xsd:string |
| http://purl.uniprot.org/citations/20533548 | http://purl.uniprot.org/core/author | "Li C."xsd:string |
| http://purl.uniprot.org/citations/20533548 | http://purl.uniprot.org/core/author | "Yao Q."xsd:string |
| http://purl.uniprot.org/citations/20533548 | http://purl.uniprot.org/core/author | "Wei M."xsd:string |
| http://purl.uniprot.org/citations/20533548 | http://purl.uniprot.org/core/author | "Kong B."xsd:string |
| http://purl.uniprot.org/citations/20533548 | http://purl.uniprot.org/core/author | "Mengesha A."xsd:string |
| http://purl.uniprot.org/citations/20533548 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/20533548 | http://purl.uniprot.org/core/name | "Int J Cancer"xsd:string |
| http://purl.uniprot.org/citations/20533548 | http://purl.uniprot.org/core/pages | "1783-1792"xsd:string |
| http://purl.uniprot.org/citations/20533548 | http://purl.uniprot.org/core/title | "Micro-RNA-21 regulates TGF-beta-induced myofibroblast differentiation by targeting PDCD4 in tumor-stroma interaction."xsd:string |
| http://purl.uniprot.org/citations/20533548 | http://purl.uniprot.org/core/volume | "128"xsd:string |
| http://purl.uniprot.org/citations/20533548 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20533548 |
| http://purl.uniprot.org/citations/20533548 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20533548 |
| http://purl.uniprot.org/uniprot/Q53EL6#attribution-75B31CC6C4B44DDB7730901FFDFAE106 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20533548 |