| http://purl.uniprot.org/citations/20534588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20534588 | http://www.w3.org/2000/01/rdf-schema#comment | "Vertebrate muscle differentiation is coordinated by an intricate network of transcription factors requiring proliferating myogenic precursors to withdraw irreversibly from the cell cycle. Recent studies have implicated a large number of microRNAs exerting another layer of control in many aspects of muscle differentiation. By annealing to short recognition sequences in the 3'-untranslated region, microRNAs attenuate target gene expression through translation repression or mRNA degradation. Here, we show that miR-214 promotes myogenic differentiation in mouse C2C12 myoblasts at a step preceding the induction of p21 and myogenin. Blocking miR-214 function with a 2'-O-methylated double-stranded inhibitor maintained C2C12 cells in the active cell cycle, thereby inhibiting the myogenic differentiation. By global gene expression profiling, we identified the proto-oncogene N-ras as one of miR-214 targets. Furthermore, manipulating the N-Ras level with small interfering RNA or adenovirus-mediated forced expression either augmented or attenuated the effect of miR-214, respectively. Thus, our data uncovered a novel microRNA-mediated mechanism that controls myogenic differentiation."xsd:string |
| http://purl.uniprot.org/citations/20534588 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.115824"xsd:string |
| http://purl.uniprot.org/citations/20534588 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/20534588 | http://purl.uniprot.org/core/author | "Zhang Z.D."xsd:string |
| http://purl.uniprot.org/citations/20534588 | http://purl.uniprot.org/core/author | "Cheng S.Y."xsd:string |
| http://purl.uniprot.org/citations/20534588 | http://purl.uniprot.org/core/author | "Yue S."xsd:string |
| http://purl.uniprot.org/citations/20534588 | http://purl.uniprot.org/core/author | "Zhu M.S."xsd:string |
| http://purl.uniprot.org/citations/20534588 | http://purl.uniprot.org/core/author | "Luo X.J."xsd:string |
| http://purl.uniprot.org/citations/20534588 | http://purl.uniprot.org/core/author | "Xiong A.W."xsd:string |
| http://purl.uniprot.org/citations/20534588 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20534588 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/20534588 | http://purl.uniprot.org/core/pages | "26599-26607"xsd:string |
| http://purl.uniprot.org/citations/20534588 | http://purl.uniprot.org/core/title | "MicroRNA-214 promotes myogenic differentiation by facilitating exit from mitosis via down-regulation of proto-oncogene N-ras."xsd:string |
| http://purl.uniprot.org/citations/20534588 | http://purl.uniprot.org/core/volume | "285"xsd:string |
| http://purl.uniprot.org/citations/20534588 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20534588 |
| http://purl.uniprot.org/citations/20534588 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20534588 |
| http://purl.uniprot.org/uniprot/P08556#attribution-F856970B978243CAE4A102797EFD6BA6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20534588 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JE25-mappedCitation-20534588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20534588 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGM2-mappedCitation-20534588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20534588 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGP4-mappedCitation-20534588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20534588 |
| http://purl.uniprot.org/uniprot/#_E9PVD5-mappedCitation-20534588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20534588 |
| http://purl.uniprot.org/uniprot/#_Q53WZ3-mappedCitation-20534588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20534588 |
| http://purl.uniprot.org/uniprot/#_Q62078-mappedCitation-20534588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20534588 |
| http://purl.uniprot.org/uniprot/#_P08556-mappedCitation-20534588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20534588 |