| http://purl.uniprot.org/citations/20534671 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20534671 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20534671 | http://www.w3.org/2000/01/rdf-schema#comment | "The bone morphogenetic protein (BMP) signaling pathway regulates multiple developmental and homeostatic processes. Mutations in the pathway can cause a variety of somatic and hereditary disorders in humans. Multiple levels of regulation, including extracellular regulation, ensure proper spatiotemporal control of BMP signaling in the right cellular context. We have identified a modulator of the BMP-like Sma/Mab pathway in C. elegans called DRAG-1. DRAG-1 is the sole member of the repulsive guidance molecule (RGM) family of proteins in C. elegans, and is crucial in regulating body size and mesoderm development. Using a combination of molecular genetic and biochemical analyses, we demonstrate that DRAG-1 is a membrane-associated protein that functions at the ligand-receptor level to modulate the Sma/Mab pathway in a cell-type-specific manner. We further show that DRAG-1 positively modulates this BMP-like pathway by using a novel Sma/Mab-responsive reporter. Our work provides a direct link between RGM proteins and BMP signaling in vivo and a simple and genetically tractable system for mechanistic studies of RGM protein regulation of BMP pathways."xsd:string |
| http://purl.uniprot.org/citations/20534671 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.051615"xsd:string |
| http://purl.uniprot.org/citations/20534671 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.051615"xsd:string |
| http://purl.uniprot.org/citations/20534671 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/20534671 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/20534671 | http://purl.uniprot.org/core/author | "Shi H."xsd:string |
| http://purl.uniprot.org/citations/20534671 | http://purl.uniprot.org/core/author | "Shi H."xsd:string |
| http://purl.uniprot.org/citations/20534671 | http://purl.uniprot.org/core/author | "Tian C."xsd:string |
| http://purl.uniprot.org/citations/20534671 | http://purl.uniprot.org/core/author | "Tian C."xsd:string |
| http://purl.uniprot.org/citations/20534671 | http://purl.uniprot.org/core/author | "Foehr M.L."xsd:string |
| http://purl.uniprot.org/citations/20534671 | http://purl.uniprot.org/core/author | "Foehr M.L."xsd:string |
| http://purl.uniprot.org/citations/20534671 | http://purl.uniprot.org/core/author | "Vatamaniuk O.K."xsd:string |
| http://purl.uniprot.org/citations/20534671 | http://purl.uniprot.org/core/author | "Vatamaniuk O.K."xsd:string |
| http://purl.uniprot.org/citations/20534671 | http://purl.uniprot.org/core/author | "Sen D."xsd:string |
| http://purl.uniprot.org/citations/20534671 | http://purl.uniprot.org/core/author | "Sen D."xsd:string |
| http://purl.uniprot.org/citations/20534671 | http://purl.uniprot.org/core/author | "Plavskin Y."xsd:string |
| http://purl.uniprot.org/citations/20534671 | http://purl.uniprot.org/core/author | "Plavskin Y."xsd:string |
| http://purl.uniprot.org/citations/20534671 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20534671 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20534671 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/20534671 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/20534671 | http://purl.uniprot.org/core/pages | "2375-2384"xsd:string |
| http://purl.uniprot.org/citations/20534671 | http://purl.uniprot.org/core/pages | "2375-2384"xsd:string |